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Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation
BackgroundTestosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived...
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Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice
BackgroundNeoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized...
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USP8 promotes the tumorigenesis of intrahepatic cholangiocarcinoma via stabilizing OGT
Ubiquitination was considered to be a crucial factor in intrahepatic cholangiocarcinoma (iCCA) development. Herein, we identified Ubiquitin-specific...
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Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts
BackgroundThe encapsulation of circular RNAs (circRNAs) into extracellular vesicles (EVs) enables their involvement in intercellular communication...
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GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a hypoxic microenvironment, a high rate of heterogeneity as well as a high likelihood of...
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RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
BackgroundGlycolysis is critical for harvesting abundant energy to maintain the tumor microenvironment in malignant tumors. Retinoic acid-related...
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In Vivo Analysis of Tumor-Associated Macrophages in the Tumor Microenvironment
In most solid cancers, tumor-associated macrophages (TAMs) infiltrating the tumor microenvironment (TME) represent a major population of...
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Toosendanin targeting eEF2 impedes Topoisomerase I & II protein translation to suppress esophageal squamous cell carcinoma growth
BackgroundAlthough molecular targets such as HER2, TP53 and PIK3CA have been widely studied in esophageal cancer, few of them were successfully...
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Origin and evolution of pentanucleotide repeat expansions at the familial cortical myoclonic tremor with epilepsy type1 - SAMD12 locus
Familial cortical myoclonic tremor with epilepsy type 1 (FCMTE1) is caused by (TTTTA)exp(TTTCA)exp repeat expansions in SAMD12 , while pure (TTTTA)exp...
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A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
BackgroundImmunotherapy is effective only in limited patients. It is urgent to discover a novel biomarker to predict immune cells infiltration status...
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Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma
Signal transducer and activator of transcription 3 (STAT3) plays an important role in the occurrence and progression of tumors, leading to resistance...
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Circ_0005015 upregulates BACH1 to promote aggressive behaviors in glioblastoma by sponging microRNA-382-5p
To investigate the potential role and molecular mechanism of circ_0005015 in GBM progression. Circ_0005015, microRNA-382-5p (miR-382-5p), and BTB...
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Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease
cGAMP-specific nucleases (poxins) are a recently described family of proteins dedicated to obstructing cyclic GMP-AMP synthase signaling (cGAS), an...
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A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
BackgroundLike its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require...
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Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
BackgroundSeveral studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogenesis. The aim of the...
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Subcutaneous Xenograft Models for Studying PDT In Vivo
The most facile, reproducible, and robust in vivo models for evaluating the anticancer efficacy of photodynamic therapy (PDT) are subcutaneous...
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Brainbow: Principle, Technique, and Applications
In the field of neuroscience, studying the intricate architecture of neuronal and glial cells forming a network in the nervous system can be...
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The identification of effective tumor-suppressing neoantigens using a tumor-reactive TIL TCR-pMHC ternary complex
Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore...
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AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis
BackgroundBasal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer due to its aggressive characteristics and lack of effective...
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Subcutaneous biodegradable scaffolds for restimulating the antitumour activity of pre-administered CAR-T cells
The efficacy of adoptive T-cell therapies based on chimaeric antigen receptors (CARs) is limited by the poor proliferation and persistence of the...
