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Macrolides in Chronic Skin Disorders
Macrolide antibiotics are widely used to treat infections of soft tissues and the respiratory tract due to their efficacy against Gram-negative and...
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Effects of neddylation on viral infection: an overview
Neddylation is a post-translational modification that plays an important role not only in cancer development but also in regulating viral infection...
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X-Linked Agammaglobulinemia: Infection Frequency and Infection-Related Mortality in the USIDNET Registry
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disorder caused by mutations in the Bruton tyrosine kinase ( BTK ) gene leading to B...
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Late Onset of Chronic Granulomatous Disease Revealed by Paecilomyces lilacinus Cutaneous Infection
Chronic granulomatous disease (CGD) is an inherited immunodeficiency due to defective leukocyte NADPH responsible for recurrent infections and...
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Evaluation of viral infection as an etiology of ME/CFS: a systematic review and meta-analysis
BackgroundMyalgic encephalitis/chronic fatigue syndrome (ME/CFS) is a long-term disabling illness without a medically explained cause. Recently...
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Modeling HIV-1 Infection in CNS via Infected Monocytes Using Immunocompetent Brain Organoids
The development of 3D-organoid models has revolutionized the way diseases are studied. Recently, our brain organoid model has been shown to...
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Biofilm-Associated Infections in Chronic Wounds and Their Management
Chronic wounds including vascular ulcers, diabetic ulcers, pressure ulcers, and burn wounds show delayed progress through the healing process. Some...
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Impact of chronic toxoplasmosis in pregnancy: association between maternal seropositivity for Toxoplasma gondii IgG antibodies and fetal growth restriction
Insults caused by acute infections during the gestational period on fetal development are known; however, new evidence suggests that chronic...
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Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
Backgroundl -Tryptophan ( l -Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most...
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Lipid droplets in pathogen infection and host immunity
As the hub of cellular lipid metabolism, lipid droplets (LDs) have been linked to a variety of biological processes. During pathogen infection, the...
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Cerebellar Degeneration Associated with HIV Infection
Objectives . To describe the features of the clinical picture and estimate the incidence of HIV-associated cerebellar degeneration in patients with...
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A prognostic model for Schistosoma japonicum infection-associated liver hepatocellular carcinoma: strengthening the connection through initial biological experiments
BackgroundNumerous studies have shown that Schistosoma japonicum infection correlates with an increased risk of liver hepatocellular carcinoma...
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Increased recognition of Q fever aortitis as a chronic manifestation of Q fever in tropical North Queensland, Australia
Aortitis is a life-threatening, manifestation of chronic Q fever. We report a series of 5 patients with Q fever aortitis who have presented to our...
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Asymptomatic Plasmodium falciparum carriage at the end of the dry season is associated with subsequent infection and clinical malaria in Eastern Gambia
BackgroundChronic carriage of asymptomatic low-density Plasmodium falciparum parasitaemia in the dry season may support maintenance of acquired...
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Transcriptomic profiling of long non-coding RNAs and messenger RNAs in the liver of mice during Toxoplasma gondii infection
BackgroundToxoplasma gondii is an intracellular protozoan parasite that can infect a wide range of warm-blooded animals, including humans. It poses...
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Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency–Associated Villous Atrophy and Norovirus Infection
PurposeAbout 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with...
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Drivers of adaptive evolution during chronic SARS-CoV-2 infections
In some immunocompromised patients with chronic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, considerable adaptive...
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Chronic Myeloid Leukaemia: A One-Hit Malignancy
Chronic myeloid leukaemia (CML) is caused by the Bcr-Abl translocation. It is otherwise genetically normal. CML is unusual in being a “single-hit”...
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Chronic Sinusitis
Chronic Sinusitis is defined as an infection of the sinuses that lasts for more than 12 weeks. It’s a very common disease and affects up to 5% of the...