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A yeast based assay establishes the pathogenicity of novel missense ACTA2 variants associated with aortic aneurysms
The ACTA2 gene codes for alpha-smooth muscle actin, a critical component of the contractile apparatus of the vascular smooth muscle cells. Autosomal...
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Defective Mitochondrial Dynamics Underlie Manganese-Induced Neurotoxicity
Perturbations in mitochondrial dynamics have been observed in most neurodegenerative diseases. Here, we focus on manganese (Mn)-induced...
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Coronavirus and the Cytoskeleton of Virus-Infected Cells
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and...
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Association of mRNA Expression Levels of LRP1 and Actin-Binding Proteins with the Development of Laryngeal and Laryngopharyngeal Squamous Cell Carcinoma
We analyzed the association of the level of mRNA expression of the main endocytosis receptor LRP1 and actin-binding proteins (ezrin, profilin-1,...
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Mechanisms and Functions of Activity-Regulated Cytoskeleton-Associated Protein in Synaptic Plasticity
Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important regulators of cognitive functions in the brain regions. As a...
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Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox
Mitochondria are essential organelles that play a significant role in various cellular processes apart from providing energy in eukaryotic cells. An...
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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse
The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced...
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Hippocampal LIMK1-mediated Structural Synaptic Plasticity in Neurobehavioral Deficits Induced by a Low-dose Heavy Metal Mixture
Humans are commonly exposed to the representative neurotoxic heavy metals lead (Pb), cadmium (Cd), and mercury (Hg). These three substances can be...
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Nutrient dynamics in coral symbiosis depend on both the relative and absolute abundance of Symbiodiniaceae species
BackgroundSymbionts provide a variety of reproductive, nutritional, and defensive resources to their hosts, but those resources can vary depending on...
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Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics
Eccentric muscle loading encompasses several unique features compared to other types of contractions. These features include increased force, work,...
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Disturbance of Mitochondrial Dynamics, Endoplasmic Reticulum–Mitochondria Crosstalk, Redox Homeostasis, and Inflammatory Response in the Brain of Glutaryl-CoA Dehydrogenase-Deficient Mice: Neuroprotective Effects of Bezafibrate
Patients with glutaric aciduria type 1 (GA1), a neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCDH) activity, commonly...
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pH-regulated single cell migration
Over the last two decades, extra- and intracellular pH have emerged as fundamental regulators of cell motility. Fundamental physiological and...
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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
BackgroundColorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is...
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Actin Polymerization in Apicomplexan A Structural, Functional and Evolutionary Analysis
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in...
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PHYTOCHROME-INTERACTING FACTORs trigger environmentally responsive chromatin dynamics in plants
The interplay between light receptors and PHYTOCHROME-INTERACTING FACTORs (PIFs) serves as a regulatory hub that perceives and integrates...
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Disulfidptosis: A new type of cell death
Disulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis,...
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Role of RhoG as a regulator of cellular functions: integrating insights on immune cell activation, migration, and functions
BackgroundRhoG is a multifaceted member of the Rho family of small GTPases, sharing the highest sequence identity with the Rac subfamily members. It...
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Exploring Scopoletin's Therapeutic Efficacy in DSS-Induced Ulcerative Colitis: Insights into Inflammatory Pathways, Immune Modulation, and Microbial Dynamics
This study aimed to investigate the therapeutic potential of scopoletin in ulcerative colitis, with a primary focus on its impact on crucial...
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Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling
Restenosis after angioplasty is caused usually by neointima formation characterized by aberrant vascular smooth muscle cell (VSMC) dedifferentiation....
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Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart Failure with Molecular Hydrogen
We studied the effect of molecular hydrogen (H 2 ) on the content of 2,3-diphosphoglyceric acid (2,3-DPG), ATP, malondialdehyde, and catalase activity...