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Tackling Pain Associated with Rheumatoid Arthritis: Proton-Sensing Receptors
Rheumatoid arthritis (RA), characterized by chronic inflammation of synovial joints, is often associated with ongoing pain and increased pain...
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Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity...
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Drug development in targeting ion channels for brain edema
Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic...
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Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat
Acid-sensing ion channels (ASICs) are a family of ion channels comprised of six subunits encoded by four genes and they are expressed throughout the...
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Naked mole-rat cortical neurons are resistant to acid-induced cell death
Regulation of brain pH is a critical homeostatic process and changes in brain pH modulate various ion channels and receptors and thus neuronal...
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Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury
BackgroundChronic pain conditions are more prevalent in women, but most preclinical studies into mechanisms of pain generation are performed using...
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Novel Analgesics with Peripheral Targets
A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or...
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Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)
Venoms from marine animals have been recognized as a new emerging source of peptide-based therapeutics. Several peptide toxins from sea anemone have...
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The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
BackgroundThe tumor acidic microenvironment, a common biochemical event in solid tumors, offers evolutional advantage for tumors cells and even...
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Topical thermal therapy with hot packs suppresses physical inactivity-induced mechanical hyperalgesia and up-regulation of NGF
We focused on the analgesic effect of hot packs for mechanical hyperalgesia in physically inactive rats. Male Wistar rats were randomly divided into...
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ASIC3 Is Required for Development of Fatigue-Induced Hyperalgesia
An acute bout of exercise can exacerbate pain, hindering participation in regular exercise and daily activities. The mechanisms underlying pain in...
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Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity
Tissue acidosis is a common feature of brain ischemia which causes neuronal injury. Activation of acid-sensing ion channel 1a (ASIC1a) plays an...
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Potentiation and Block of ASIC1a by Memantine
Acid-sensing ion channels (ASICs) are modulated by various classes of ligands, including the recently described hydrophobic monoamines, which inhibit...
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Membrane Transporters and Channels in Melanoma
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in...
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Antibodies and venom peptides: new modalities for ion channels
Ion channels play fundamental roles in both excitable and non-excitable tissues and therefore constitute attractive drug targets for myriad...
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Oncotic Cell Death in Stroke
Oncotic cell death or oncosis represents a major mechanism of cell death in ischaemic stroke, occurring in many central nervous system (CNS) cell...
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Acid-induced experimental knee pain and hyperalgesia in healthy humans
Inflammation and the related acidity in peri-articular structures may be involved in pain generation and hyperalgesia in knee osteoarthritis. This...
