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Repair of programmed DNA lesions in antibody class switch recombination: common and unique features
The adaptive immune system can diversify the antigen receptors to eliminate various pathogens through programmed DNA lesions at antigen receptor...
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Application of Single-Cell RNA Sequencing in Pancreatic Cancer and the Endocrine Pancreas
The pancreas is a complex organ composed of an endocrine (pancreatic islets) and an exocrine portion. This mixed cell population has resulted in an...
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Impact of PARP1, PARP2 & PARP3 on the Base Excision Repair of Nucleosomal DNA
DNA is constantly attacked by different damaging agents; therefore, it requires frequent repair. On the one hand, the base excision repair (BER)...
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DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance
A variety of endogenous and exogenous factors induce chemical and structural alterations in cellular DNA in addition to the errors occurring...
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Recombinant Human Deoxyribonuclease I
Human deoxyribonuclease I (DNase I) is an endonuclease that catalyzes the hydrolysis of extracellular DNA and is just one of the numerous types of...
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LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo
Long noncoding RNAs (lncRNAs) have been demonstrated to participate in neuroblastoma cisplatin resistance and tumorigenesis. LncRNA LINC00460 was...
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Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation...
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Phytocompounds-Based Approaches to Combat Oxidative Stress in Cancer
Present chapter will have the focus on the phytocompounds-based approaches to combat oxidative stress in cancer. Oxidative stress plays important...
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Nature of spontaneously arising single base substitutions in normal cells
Next-generation sequencing (NGS) of single cells and micro-dissected tissues has demonstrated that the number of somatic mutations in normal cells...
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DNA Damage Response Pathways in Cancer Predisposition and Metastasis
Genes involved in DNA damage response play pivotal functions in maintaining genome health. Upregulated DNA damage response and repair genes are...
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The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy
Despite significant advances in our understanding of tumourigenesis and cancer therapeutics, cancer continues to account for 30% of worldwide deaths....
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The biology of ependymomas and emerging novel therapies
Ependymomas are rare central nervous system tumours that can arise in the brain’s supratentorial region or posterior fossa, or in the spinal cord. In...
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Stemness and Stromal Niche: Targets in Oxidative Stress–Induced Oral Cancer
Oral cancer is the third most prevalent cancer in the world and the most common among males. Despite improvement in therapeutic strategies, the...
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Stemness and Stromal Niche: Targets in Oxidative Stress Induced Oral Cancer
Oral cancer is the third most prevalent cancer in the world and the most common among males. Despite improvement in therapeutic strategies, the...
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Mitochondrial Abnormalities and Synaptic Damage in Huntington’s Disease: a Focus on Defective Mitophagy and Mitochondria-Targeted Therapeutics
Huntington’s disease (HD) is a fatal and pure genetic disease with a progressive loss of medium spiny neurons (MSN). HD is caused by expanded...
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Strategies to Upgrade the Stem Cell Application for Brain Transplantation
Introduction: Cerebral stem cellStem cell transplantation has the potential to replace dead cells and restore lost brain functions in...
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Helicobacter pylori infection induced genome instability and gastric cancer
Genome stability and integrity are constantly challenged by exogenous insults such as bacterial infections. When genome stability is perturbed,...
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Epigenetic based synthetic lethal strategies in human cancers
Over the past decades, it is recognized that loss of DNA damage repair (DDR) pathways is an early and frequent event in tumorigenesis, occurring in...
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Genome editing approaches with CRISPR/Cas9: the association of NOX4 expression in breast cancer patients and effectiveness evaluation of different strategies of CRISPR/Cas9 to knockout Nox4 in cancer cells
BackgroundThe increasing prevalence of cancer detection necessitated practical strategies to deliver highly accurate, beneficial, and dependable...
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Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction
BackgroundDecreased heart rate variability (HRV) leads to cardiovascular diseases and increased mortality in clinical studies. However, the...
