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Genomic profiling informs diagnoses and treatment in vascular anomalies
Vascular anomalies are malformations or tumors of the blood or lymphatic vasculature and can be life-threatening. Although molecularly targeted...
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Contribution of extracellular vesicles for the pathogenesis of retinal diseases: shedding light on blood-retinal barrier dysfunction
Retinal degenerative diseases, including diabetic retinopathy (DR) and age-related macular degeneration (AMD), loom as threats to vision, causing...
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Pathological mechanisms of cigarette smoking, dietary, and sedentary lifestyle risks in vascular dysfunction: mitochondria as a common target of risk factors
In the past century, the lifespan of the human population has dramatically increased to the 80 s, but it is hindered by a limited health span to the...
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Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases
Systemic autoimmune diseases are characterized by the failure of the immune system to differentiate self from non-self. These conditions are...
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Cardiovascular Diseases and Cognitive Impairments
As life expectancy increases, combinations of cardiovascular disease (CVD) with cognitive impairment and dementia are increasingly common. Cognitive...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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Extracellular Vesicles and Ischemic Cardiovascular Diseases
Characterized by coronary artery obstruction or stenosis, ischemic cardiovascular diseases as advanced stages of coronary heart diseases commonly...
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Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...
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Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes
BackgroundAdvanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of...
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Therapeutic effects of tetrandrine in inflammatory diseases: a comprehensive review
Inflammation can be triggered by any factor. The primary pathological manifestations can be summarized as the deterioration, exudation, and...
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Autoinflammatory diseases and the kidney
The kidney represents an important target of systemic inflammation. Its involvement in monogenic and multifactorial autoinflammatory diseases (AIDs)...
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Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases
Sonic hedgehog (SHH) signaling is vital for cell differentiation and proliferation during embryonic development, yet its role in cardiac, cerebral,...
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Imaging Vascular Anatomy and Pathology of the Posterior Fossa
Neurovascular diseases of the posterior circulation represent a major cause of morbidity and mortality, which is due in large part to the eloquence...
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Strategies for modeling aging and age-related diseases
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and...
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Explainable artificial intelligence for the automated assessment of the retinal vascular tortuosity
AbstractRetinal vascular tortuosity is an excessive bending and twisting of the blood vessels in the retina that is associated with numerous health...
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Biotechnological Approaches in Infectious Diseases
Infectious conditions have a significant influence on the occurrence of illness and death worldwide. The management of human immunodeficiency virus...
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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of...
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Advancements in Single-Cell RNA Sequencing Research for Neurological Diseases
Neurological diseases are a major cause of the global burden of disease. Although the mechanisms of the occurrence and development of neurological...
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The role of NLRP3 inflammasome in aging and age-related diseases
The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are...
