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Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells
BackgroundThe C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS) acts both as an oncogenic transcriptional co-repressor...
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Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis
BackgroundNutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme...
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Substantial somatic genomic variation and selection for BCOR mutations in human induced pluripotent stem cells
We explored human induced pluripotent stem cells (hiPSCs) derived from different tissues to gain insights into genomic integrity at single-nucleotide...
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Identification of Response Elements on Promoters Using Site-Directed Mutagenesis and Chromatin Immunoprecipitation
Proximal promoters are located upstream of the transcription start sites of genes, and they contain regulatory sequences on which bind different...
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Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome editing system has been a major technological breakthrough that...
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Kv11.1 (hERG1) Channels and Cardiac Arrhythmia
The rapid delayed rectifier K+ current (IKr) is one of several outward currents that mediate repolarization of cardiac action potentials in humans...
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Phospholipase D2 is a positive regulator of sirtuin 1 and modulates p53-mediated apoptosis via sirtuin 1
Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase that plays diverse physiological roles. However, little is...
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Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum
BackgroundPlasmodium species are entirely dependent upon their host as a source of essential iron. Although it is an indispensable micronutrient,...
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Significance of hepatitis B virus capsid dephosphorylation via polymerase
BackgroundIt is generally believed that hepatitis B virus (HBV) core protein (HBc) dephosphorylation (de-P) is important for viral DNA synthesis and...
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Application of CRISPR-Cas9 for Functional Analysis in A. mexicanus
Establishing genotype–phenotype relationships is critical for understanding the genetic architecture underlying trait evolution. While functional...
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Lysine Ubiquitylation Drives Rhodopsin Protein Turnover
Rhodopsin is a G-protein-coupled receptor that is specifically and abundantly expressed in rod photoreceptors. Over 150 rhodopsin mutations cause...
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Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer
BackgroundLysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated...
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Impaired trafficking and instability of mutant kidney anion exchanger 1 proteins associated with autosomal recessive distal renal tubular acidosis
BackgroundMutations in solute carrier family 4 member 1 ( SLC4A1 ) encoding anion exchanger 1 (AE1) are the most common cause of autosomal recessive...
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An Overview of Genome Editing in Cardiovascular and Metabolic Diseases
This chapter summarizes the definition, classification, and function of genome editing and highlights the breakthroughs of genome editing in...
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CK2-mediated phosphorylation of Che-1/AATF is required for its pro-proliferative activity
BackgroundChe-1/AATF (Che-1) is an RNA polymerase II binding protein involved in several cellular processes, including proliferation, apoptosis and...
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Vaccination with a replication-defective cytomegalovirus vaccine elicits a glycoprotein B-specific monoclonal antibody repertoire distinct from natural infection
Human Cytomegalovirus (HCMV) is the leading infectious congenital infection globally and the most common viral infection in transplant recipients,...
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor
Von Willebrand disease (VWD), the most common inherited bleeding disorder in humans, is caused by quantitative or qualitative defects in von...
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Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines
BackgroundIt was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection,...
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Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens
Xenotransplantation of pig organs into people may help alleviate the critical shortage of donors which faces organ transplantation. Unfortunately,...
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BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
BackgroundBrother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and poor prognosis in...
