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Targeting Molecular and Cellular Mechanisms in Asthma
Many a times, a very thin line exists between physiology and pathology. Airway obstruction seen in the asthmatic subjects is exemplary of such...
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Multifunctional Nanoparticles for Targeting Cancer Nanotheranostics
This chapter focuses on the potential of various multifunctional nanostructures widely employed for cancer nanotheranostics. In specific,...
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New Approaches in Cancer Research: Stem Cell Research, Translational Research, Immunotherapy, and Others
Despite relentless efforts from the scientific community, emergence of an optimal anticancer medicament is yet an elusive concept. In this chapter,...
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Monoclonal Antibodies to CTLA-4 with Focus on Ipilimumab
The immune checkpoint cytotoxic T lymphocyte-associated antigen 4 (CTLA-4 or CD152) is a negative regulator of T-cell-mediated immune responses which...
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Drug Delivery Approaches and Imaging Techniques for Brain Tumor
Brain tumor is an abnormal growth of tissue in the CNS that can interrupt the brain function and proved challenging to treat, largely owing to the...
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Effect of cortical extracellular GABA on motor response
To elucidate how the flattening of sensory tuning due to a deficit in tonic inhibition slows motor responses, we simulated a neural network model in...
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CRISPR-based diagnostics
The accurate and timely diagnosis of disease is a prerequisite for efficient therapeutic intervention and epidemiological surveillance. Diagnostics...
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Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow
Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour,...
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Balloon expandable coronary stent materials: a systematic review focused on clinical success
Balloon expandable coronary stenting has revolutionized the field of interventional cardiology as a potential, minimally invasive modality for...
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Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used...
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Advances in MRI-Based Anatomy of the Human Hypothalamus and Effects of the Hypothalamic Neuropeptide Oxytocin on Brain BOLD Signals
In humans, the hypothalamus makes up less than 1% of the total brain volume. Yet, this small structure is involved in various metabolic, behavioral,...
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Vaccines as Immunotherapy
Cancer is a disorder wherein normal cells get transformed and lose control over cell division potential leading to tumor formation. Various factors...
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Advanced technologies for the preservation of mammalian biospecimens
The three classical core technologies for the preservation of live mammalian biospecimens—slow freezing, vitrification and hypothermic storage—limit...
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An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy
For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment approach. However, the surgery is...
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Increased Susceptibility of Atrial Fibrillation Induced by Hyperuricemia in Rats: Mechanisms and Implications
High levels of serum uric acid is closely associated with atrial fibrillation (AF); nonetheless, the detailed mechanisms remain unknown. Therefore,...
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Current Trends in Engineered Gold Nanoparticles for Cancer Therapy
In recent years, engineered smart nanomaterials are considered ideal candidates for the efficient treatment of cancers. Among all the engineered...
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Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of new drugs and less...
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Introduction to Chronic Respiratory Diseases: A Pressing Need for Novel Therapeutic Approaches
Chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease, cystic fibrosis, and lung cancer are among the leading causes of...
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Recent updates on chimeric antigen receptor T cell therapy for hepatocellular carcinoma
Chimeric antigen receptor T cell (CAR-T) therapy is novel tumor immunotherapy that enables T cells to specifically recognize tumor-associated...
