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Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
Spinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal...
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Fatty ethanolamide of Bertholletia excelsa triglycerides (Brazil nuts): anti-inflammatory action and acute toxicity evaluation in Zebrafish (Danio rerio)
Fatty amides ( N -alkylamides) are bioactive lipids that are widely distributed in microorganisms, animals, and plants. The low yield in the extraction...
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Recent Development in Chronic Inflammation Research and Mangroves as Potential Source of Anti-inflammatory Agents
The chronic inflammatory processes are considered as important factors in the development and progression of micro- as well as macro-vascular...
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Drug-drug interaction assessment based on a large-scale spontaneous reporting system for hepato- and renal-toxicity, and thrombocytopenia with concomitant low-dose methotrexate and analgesics use
BackgroundMethotrexate (MTX) is the cornerstone of rheumatoid arthritis (RA) treatment and is highly effective with low-dose intermittent...
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Characteristics of Neutrophil Migration and Function in Acute Inflammation Induced by Zymosan and Carrageenan in the Mice Air Pouch Model
Deciphering the complex and redundant process of acute inflammation remains challenging. The failure of numerous clinical trials assessing...
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application
Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive...
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Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar tissue, known as the...
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Risk estimation of fetal adverse effects after short-term second trimester exposure to non-steroidal anti-inflammatory drugs: a literature review
PurposeNon-steroidal anti-inflammatory drugs (NSAIDs) are not recommended in the 3rd trimester of pregnancy due to known fetal adverse effects in an...
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The impact of β-glucan on the therapeutic outcome of experimental Trichinella spiralis infection
Trichinellosis is a cosmopolitan zoonosis that is caused mainly by Trichinella spiralis infection. The human disease ranges from mild to severe and...
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A rare case of phenobarbital-induced leukocytoclastic vasculitis
Drug hypersensitivity reactions (DHRs) manifested as vasculitis are rare. Antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), sulphonamides,...
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Role of intracellular signaling pathways and their inhibitors in the treatment of inflammation
Inflammation is not only a defense mechanism of the innate immune system against invaders, but it is also involved in the pathogenesis of many...
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Ameliorative effects of Atriplex crassifolia (C.A.Mey) on pain and inflammation through modulation of inflammatory biomarkers and GC–MS-based metabolite profiling
Atriplex crassifolia (A. crassifolia) is a locally occurring member of Chenopodiaceae family that has been used in folk medicine for the treatment of...
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Analysis of non-volatile metabolites and quantitation of the anti-arthritic alkaloid sinomenine from blood fruit (Haematocarpus validus (Miers) Bakh.f. ex Forman)
Haematocarpus validus (Miers) Bakh. f. ex Forman, a lesser-known fruit and medicinal plant of high nutraceutical and medicinal value, is used as...
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The anti-inflammatory role of SSRI and SNRI in the treatment of depression: a review of human and rodent research studies
RationaleDepression has the topmost prevalence of all psychiatric diseases. It is characterized by a high recurrence rate, disability, and numerous...
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“Deficiency in ELF4, X-Linked”: a Monogenic Disease Entity Resembling Behçet’s Syndrome and Inflammatory Bowel Disease
Defining monogenic drivers of autoinflammatory syndromes elucidates mechanisms of disease in patients with these inborn errors of immunity and can...
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Terminalia ferdinandiana Exell. extracts reduce pro-inflammatory cytokine and PGE2 secretion, decrease COX-2 expression and down-regulate cytosolic NF-κB levels
Based on their high antioxidant capacity and noteworthy phytochemistry, Terminalia ferdinandiana fruit and leaves have attracted considerable recent...
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Prevention of colistin-induced neurotoxicity: a narrative review of preclinical data
Polymyxin E or colistin is an effective antibiotic against MDR Gram-negative bacteria. Due to unwanted side effects, the use of this antibiotic has...
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Comparative Treatment Persistence with Bone-Targeting Agents Among Asian Patients with Bone Metastases from Solid Tumors: A Multinational Retrospective Cohort Study
BackgroundThe efficacy of bone-targeting agents has been confirmed, but the generalizability of results to Asia is in question.
Objective ...
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Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...
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Inflammation and Pain
Inflammation is the body’s natural response to injury or the infiltration of a foreign substance. The process is defined by five cardinal signs:...