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The DOCK protein family in vascular development and disease
The vascular network is established and maintained through the processes of vasculogenesis and angiogenesis, which are tightly regulated during...
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Expression and prognostic roles of PRDXs gene family in hepatocellular carcinoma
BackgroundAs the fourth leading cause of cancer-related death in the world, the therapeutic effect and 5-year overall survival of hepatocellular...
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Biomarker prediction in autism spectrum disorder using a network-based approach
BackgroundAutism is a neurodevelopmental disorder that is usually diagnosed in early childhood. Timely diagnosis and early initiation of treatments...
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The link between glycemic control measures and eye microvascular complications in a clinical cohort of type 2 diabetes with microRNA-223-3p signature
BackgroundType 2 diabetes (T2D) is a critical healthcare challenge and priority in Qatar which is listed amongst the top 10 countries in the world,...
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Bevacizumab induces ferroptosis and enhances CD8+ T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9
Bevacizumab is a recombinant humanized monoclonal immunoglobulin (Ig) G1 antibody of VEGF, and inhibits angiogenesis and tumor growth in...
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MYSM1 inhibits human colorectal cancer tumorigenesis by activating miR-200 family members/CDH1 and blocking PI3K/AKT signaling
BackgroundHistone epigenetic modification disorder is an important predisposing factor for the occurrence and development of many cancers, including...
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Circulating MicroRNAs as Potential Biomarkers for Ischemic Stroke in Patients with Asymptomatic Intracranial Artery Stenosis
Circulating microRNAs have been shown to be biomarkers of various diseases. We aimed to investigate whether circulating microRNA can serve as a...
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Role of the microRNA-29 family in myocardial fibrosis
Myocardial fibrosis (MF) is an inevitable pathological process in the terminal stage of many cardiovascular diseases, often leading to serious...
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The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines
BackgroundGlioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell...
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Phytochemistry, pharmacology, and medical uses of Oldenlandia (family Rubaceae): a review
The Oldenlandia genus comprises approximately 240 species of plants, yet only a limited number of these have been investigated for their chemical...
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MicroRNAs-mediated regulation pathways in rheumatic diseases
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are two common rheumatic disorders marked by persistent inflammatory joint disease....
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A Novel Mutation in COL4A1 Gene in a Chinese Family with Pontine Autosomal Dominant Microangiopathy and Leukoencephalopathy
Pontine autosomal dominant microangiopathy and leukoencephalopathy (PADMAL) is a rare hereditary cerebral small vessel disease. We report a novel...
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Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients
BackgroundIn our previous study it was found that CENPL was overexpressed in hepatocellular carcinoma and significantly predicted patient's...
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Elucidation of the effects of 2,5-hexandione as a metabolite of n-hexane on cognitive impairment in leptin-knockout mice (C57BL/6-Lepem1Shwl/Korl)
Exposure to n-hexane and its metabolite 2,5-hexandione (HD) is a well-known cause of neurotoxicity, particularly in the peripheral nervous system. To...
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Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858
BackgroundExosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium...
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Enhanced autophagy interacting proteins negatively correlated with the activation of apoptosis-related caspase family proteins after focal ischemic stroke of young rats
BackgroundNeuronal injury induced in young rats by cerebral ischemia reperfusion (CIR) is known to differ substantially from that in adult rats. In...
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MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding protein
Nuclear factor kappa B (NF-κB) activation contributes to many vascular inflammatory diseases. The present study tested the hypothesis that...
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Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4
To investigate the mechanism of Schisandrin B ( Sch B ) on the inflammation in LPS-induced sepsis. Sepsis mouse model was established by injecting LPS....
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Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant
MicroRNAs have gained popularity as a potential treatment for many diseases, including stroke. This study identifies and characterizes a specific...
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Solute Carrier Family 27 Member 6 (SLC27A6) Possibly Promotes the Proliferation of Papillary Thyroid Cancer by Regulating c-MYC
To investigate the expression and mechanism of LSC27A6 in papillary thyroid cancer (PTC). We analyzed the differential expression of SLC27A6 in PTC...
