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Modulatory Effects of Stem Cells on Oxidative Stress and Antioxidant Defense System in Cancer
Oxidative stress has been implicated in the development and progress of various types of cancer, and generally the increase of reactive oxygen...
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Exploring Nrf2 as a therapeutic target in testicular dysfunction
Testicular dysfunction, a major contributory factor to infertility, has received a lot of attention over the recent years. Several studies have...
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Integrated genomic and DNA methylation analysis of patients with advanced non-small cell lung cancer with brain metastases
BackgroundBrain metastasis is a common and lethal complication of non-small cell lung cancer (NSCLC). It is mostly diagnosed only after symptoms...
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Molecular mechanisms involved in therapeutic effects of natural compounds against cisplatin-induced cardiotoxicity: a review
Cisplatin is a widely used chemotherapeutic agent for the treatment of various cancers. However, the clinical use of cisplatin is limited by its...
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Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
BackgroundThe devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after...
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Tricarboxylic acid cycle metabolites: new players in macrophage
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid...
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Malvidin alleviates LPS-induced septic intestinal injury through the nuclear factor erythroid 2-related factor 2/reactive oxygen species/NLRP3 inflammasome pathway
Emerging evidence suggests that the gastrointestinal tract plays a crucial role in the pathophysiology of sepsis, a leading cause of mortality among...
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Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan
Adenostemma lavenia (L.) Kuntze (Asteraceae) is widely distributed in tropical regions of East Asia, and both A. lavenia and A. madurense (DC) are...
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SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway
Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to...
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Antimalarial Drugs and Drug Resistance
WHO estimated 241 million malaria cases in 2020 in 85 different malaria-endemic countries, more than in 2019. The reduction of cases due to...
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Disulfidptosis: A new type of cell death
Disulfidptosis is a novel form of cell death that is distinguishable from established programmed cell death pathways such as apoptosis, pyroptosis,...
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The promising antioxidant effects of lignans: Nrf2 activation comes into view
Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several...
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Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in mainland Tanzania, 2019
BackgroundArtemisinin-based combination therapy (ACT) has been a major contributor to the substantial reductions in global malaria morbidity and...
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Isolation of Phytohormone trans-Zeatin: Potential Oxidant Scavenger and Anti-Aging Compound
AbstractIn all parts of the world, dementia rates are rising rapidly, particularly in Western nations, where it accounts for roughly 60% of cases and...
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Dynamic changes in genetic diversity, drug resistance mutations, and treatment outcomes of falciparum malaria from the low-transmission to the pre-elimination phase on the islands of São Tomé and Príncipe
BackgroundWith effective vector control and case management, substantial progress has been made towards eliminating malaria on the islands of São...
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Allyl isothiocyanate regulates oxidative stress, inflammation, cell proliferation, cell cycle arrest, apoptosis, angiogenesis, invasion and metastasis via interaction with multiple cell signaling pathways
Cancer growth is a molecular mechanism initiated by genetic and epigenetic modifications that are involved in cell proliferation, differentiation,...
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Molecular signatures of inherited and acquired sporadic late onset nemaline myopathies
Acquired sporadic late onset nemaline myopathy (SLONM) and inherited nemaline myopathy (iNM) both feature accumulation of nemaline rods in muscle...
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Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy...
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Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through...
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Putative molecular targets for vitamin A in neutralizing oxidative stress in acute and chronic pancreatitis — a systematic review
Acute pancreatitis (AP) and chronic pancreatitis (CP) are debilitating diseases of gastrointestinal tract and constitute great threat for human...
