Search
Search Results
-
Blood Cortisol as a Biomarker in Intensive Care Unit
Despite some issues are limiting the use of blood cortisol as an excellent biomarker in intensive care units, it is seen in literature that blood...
-
In Vitro Development of Mouse and Human NK Cells from Hematopoietic Progenitor Cells
Natural killer (NK) cells are lymphocytes that play an important role at clearing virally infected or cancer cells. Their potential and role in...
-
Corticosteroids in Immunosuppression
Corticosteroids have been utilized as mainstay pharmacological intervention for successful organ transplantation since the beginning. Several...
-
Establishing conditions for the generation and maintenance of estrogen receptor-positive organoid models of breast cancer
Patient-derived organoid models of estrogen receptor-positive (ER+) breast cancer would provide a much-needed tool to understand drug resistance and...
-
Partial-Volume Irradiation of Murine Tumors
Radiotherapy is a widely used approach for cancer treatment. However, delivering a single high dose of radiation to bulky tumors can be challenging...
-
Determination of Endothelial Barrier Resistance by Electric Cell-Substrate Impedance Sensing (ECIS) System
Endothelial cells lining the inner surface of blood vessels and lymphatic vessels play an indispensable role in vascular homeostasis. Apart from...
-
Quality by Design (QbD) Concept for Formulation of Oral Formulations for Tablets
Pharmaceutical scientists use the Quality by Design (QbD) approach to develop robust oral dosage forms, such as tablets and pellets, by considering...
-
An In Vitro Bilayer Model of Human Primary Retinal Pigment Epithelial and Choroid Endothelial Cells for Permeability Studies
The blood-retinal barrier (BRB) present in the posterior chamber of the eye plays a major role in maintaining the proper function and integrity of...
-
Potential roles of the interactions between gut microbiota and metabolites in LPS-induced intrauterine inflammation (IUI) and associated preterm birth (PTB)
BackgroundPrenatal exposure to intrauterine inflammation (IUI) is a crucial event in preterm birth (PTB) pathophysiology, increasing the incidence of...
-
Ruxolitinib Rescues Multiorgan Clinical Autoimmunity in Patients with APS-1
Autoimmune polyendocrine syndrome type-1 (APS-1) is caused by mono- or biallelic loss-of-function variants of the autoimmune regulator gene AIRE ...
-
Investigating a Novel Two-Bag N-Acetylcysteine Regimen for Acetaminophen Toxicity
BackgroundAcetaminophen toxicity remains one of the most common causes of liver failure and is treated with a course of n-acetylcysteine (NAC). This...
-
Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality
Mechanisms underlying the SARS-CoV-2-triggered hyperacute thrombo-inflammatory response that causes multi-organ damage in coronavirus disease 2019...
-
Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling
BackgroundWe previously found that high-dose methylprednisolone increased the incidence of critical illness-related corticosteroid insufficiency...
-
Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related...
-
Breast Cancer Xenograft Murine Models
Mice are used as model organisms to understand the pathological basis of a variety of human diseases, including breast cancer. Both immunocompetent...
-
Immunofluorescent Staining of Human Hepatic Multicellular Spheroids: A Model for Studying Liver Diseases
In vitro studies on liver diseases, such as non-alcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma, are traditionally performed in...
-
Cancer and Hypercalcemia
Alterations of calcium homeostasis leading to hypercalcemia can occur at three different levels: the bone (increased osteoclast activity), kidney...
-
Regulatory Role of Nitric Oxide in Cutaneous Inflammation
Nitric oxide (NO), a signaling molecule, regulates biological functions in multiple organs/tissues, including the epidermis, where it impacts...
-
The Role of the Glutamate System in Posttraumatic Stress Disorder and Glutamate-Based Treatments
Posttraumatic Stress Disorder (PTSD) is a chronic mental illness with limited options for treatment, characterized by intrusive memory of trauma,...
-
