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Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum
Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses...
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The Role of ROS in Chemical Carcinogenesis Induced by Lead, Nickel, and Chromium
Metals such as lead (Pb), nickel (Ni), and chromium (Cr) are pervasive and persistent environmental contaminants employed in a number of industrial...
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Genome-wide ATAC-see screening identifies TFDP1 as a modulator of global chromatin accessibility
Chromatin accessibility is a hallmark of active regulatory regions and is functionally linked to transcriptional networks and cell identity. However,...
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Endoplasmic reticulum stress and mitochondrial injury are critical molecular drivers of AlCl3-induced testicular and epididymal distortion and dysfunction: protective role of taurine
Aluminum, the third most plentiful metal in the Earth’s crust, has potential for human exposure and harm. Oxidative stress plays an essential role in...
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Epigenetics and Medical Biotechnology
The field of epigenetics deals with the study of processes that lead to changes in gene expression without changing the underlying DNA sequence....
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Viral and host mediators of non-suppressible HIV-1 viremia
Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on antiretroviral therapy (ART) without evidence of ART non-adherence...
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Epigenetic mechanisms regulate sex differences in cardiac reparative functions of bone marrow progenitor cells
Historically, a lower incidence of cardiovascular diseases (CVD) and related deaths in women as compared with men of the same age has been attributed...
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The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4 + T cells, pose the primary...
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Diagnostic Methods for Ring Chromosomes
The molecular characterization of ring chromosome (RC) structural aberrations requires the use of cytogenomic techniques. The first RCs were...
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Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism
BackgroundIndividuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism...
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Potential protective effect of 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study
Acute lung injury is a serious condition accounting for the majority of acute respiratory failure. Bleomycin (BLM) is an antibiotic that was first...
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The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research
Cytogenetic analysis has traditionally focused on the clonal chromosome aberrations, or CCAs, and considered the large number of diverse non-clonal...
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Loss of epidermal MCPIP1 is associated with aggressive squamous cell carcinoma
BackgroundSquamous cell carcinoma (SCC) of the skin is a common form of nonmelanoma skin cancer. Monocyte chemotactic protein 1-induced protein 1...
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HIRA vs. DAXX: the two axes sha** the histone H3.3 landscape
H3.3, the most common replacement variant for histone H3, has emerged as an important player in chromatin dynamics for controlling gene expression...
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Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants
Autism spectrum disorder (ASD) is a collection of neurodevelopmental disorders characterized by deficits in social communication and restricted,...
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Three-dimensional genome organization in immune cell fate and function
Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization...
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Histone post-translational modifications — cause and consequence of genome function
Much has been learned since the early 1960s about histone post-translational modifications (PTMs) and how they affect DNA-templated processes at the...
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SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence
SIRT1, a member of the mammalian sirtuin family, is a nicotinamide adenosine dinucleotide (NAD)-dependent deacetylase with key roles in aging-related...
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TE Density: a tool to investigate the biology of transposable elements
BackgroundTransposable elements (TEs) are powerful creators of genotypic and phenotypic diversity due to their inherent mutagenic capabilities and in...
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Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective
Purpose of ReviewThe main obstacle to an HIV-1 cure is the reservoir of HIV-1 infected cells. While antiretroviral therapy (ART) eliminates the HIV-1...
