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Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine
The dedicator of cytokinesis 2(DOCK2) protein, an atypical guanine nucleotide exchange factor (GEFs), is a member of the DOCKA protein subfamily....
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The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs
Lymphoid organs consist of immune cells and stromal cells. The stromal cells produce various cytokines that support the development, maintenance, and...
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De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells
BackgroundAnaplastic large cell lymphoma positive for ALK (ALK+ ALCL) is a rare type of non-Hodgkin lymphoma. This lymphoma is caused by chromosomal...
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Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment
BackgroundWhen Theileria annulata infects host cells, it undertakes unlimited proliferation as tumor cells. Although the transformed cells will...
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Successful Immune Reconstitution in a Patient with a TYK2 Deficiency after Allogeneic Stem Cell Transplantation from Unrelated Donors
A boy with primary immunodeficiency, caused by a tyrosine kinase 2 ( TYK2 ) mutation, presented with immune defects and a lifelong history of severe...
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The Critical Biomarkers Identification of Insulin Signaling Involved in Initiating cAMP Signaling Mediated Salivary Secretion in Sjogren Syndrome: Transcriptome Sequencing in NOD Mice Model
BackgroundSjogren’s syndrome (SS) is an autoimmune disorder characterized by the destruction of exocrine glands, resulting in dry mouth and eyes....
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Early-life respiratory infections and developmental immunity determine lifelong lung health
Respiratory infections are common in infants and young children. However, the immune system develops and matures as the child grows, thus the effects...
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Comparison of the pathogenicity of porcine reproductive and respiratory syndrome virus (PRRSV)-1 and PRRSV-2 in pregnant sows
To date, few studies related to the evaluation of the pathogenicity of different PRRSV isolates using a reproductive model have been undertaken, and...
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Models for Drug Individualization: Patient to Population Level
Multiple drug dosing models have been developed which try to address optimal drug therapy for the individual patient based on population data. Drug...
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Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells
Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse...
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Immunology in Medical Biotechnology
Mammalian immune system is represented by a veneered defense system comprising of both innate and adaptive immune responses. There is a continuous...
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Tissue-resident immunity in the female and male reproductive tract
The conception of how the immune system is organized has been significantly challenged over the last years. It became evident that not all...
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TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors downstream of the WNT signalling pathway and are essential for...
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Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis
BackgroundThe thymus plays an essential role in the pathogenesis of myasthenia gravis (MG). In patients with MG, natural regulatory T cells (nTreg),...
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The telomere complex and the origin of the cancer stem cell
Exquisite regulation of telomere length is essential for the preservation of the lifetime function and self-renewal of stem cells. However, multiple...
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Severe Combined Immunodeficiency
Severe combined immunodeficiencies (SCID) are a heterogeneous group of rare, genetic diseases resulting in profoundly impaired adaptive immune...
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In vitro models and ex vivo systems used in inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn’s disease are types of inflammatory...
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Reduced cell invasion may be a characteristic of placental defects in pregnant women of advanced maternal age at single-cell level
The mechanisms underlying pregnancy complications caused by advanced maternal age (AMA) remain unclear. We analyzed the cellular signature and...
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T Cell Subsets and Immune Homeostasis
T cells are a heterogeneous group of cells that can be classified into different subtypes according to different classification methods. The body’s...
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An overview of mouse models of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective...
