Search
Search Results
-
Machine Learning and Deep Learning Promote Computational Toxicology for Risk Assessment of Chemicals
In order to advance the field of computational toxicology forward, it is vital to leverage new machine learning and deep learning algorithms....
-
Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called...
-
COVID-19 pandemic and the protection of workers’ health from disinfectant chemicals
Objective and methodsThis study examines the protection of workers from the “COVID-19” pandemic, especially healthcare workers, disinfection workers,...
-
Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies
The EU Directive 2010/63/EU on the protection of animals used for scientific purposes and other EU regulations, such as REACH and the Cosmetic...
-
Soluble Guanylyl Cyclase Alpha1 Subunit as a Biomarker of Toxicity: Applications to Investigate Endocrine-Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are a growing group of naturally occurring and synthetic substances in the environment that negatively impacts...
-
Computational Applications on Food Contact Chemicals as Nuclear Receptor Binders
Humans, but also animals, are exposed to chemicals in everyday life. Many of these compounds are present in our food as food contact chemicals...
-
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update
This is an overview of the metabolic activation of drugs, natural products, physiological compounds, and general chemicals by the catalytic activity...
-
Assessing the health hazard originated via pesticide chemicals in human through rabbit model in agricultural production system in Bangladesh
BackgroundThe use of chemical pesticides in develo** countries like Bangladesh and their impacts on human health and food security is a global...
-
An Expert System for Monitoring the Status of Patients after Exposure to Industrial Poisonous Chemicals
The relevant problem of increasing the quality of medical care provision to industrial workers exposed to harmful chemical substances in combination...
-
Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment
In view of the need to enhance the assessment of consumer products called for in the EU Chemicals Strategy for Sustainability, we developed a...
-
Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health
Environmental endocrine-disrupting chemicals (EDCs) are xenobiotic compounds that are frequently contacted in daily life. With the species and...
-
In silico prediction of toxicity and its applications for chemicals at work
Objective and methodsThis study reviewed the concept of in silico prediction of chemical toxicity for prevention of occupational cancer and future...
-
Gene X environment: the cellular environment governs the transcriptional response to environmental chemicals
BackgroundAn individual’s response to environmental exposures varies depending on their genotype, which has been termed the gene-environment...
-
Racial/Ethnic Disparities in Pregnancy and Prenatal Exposure to Endocrine-Disrupting Chemicals Commonly Used in Personal Care Products
Purpose of ReviewEndocrine-disrupting chemical (EDC) exposure during pregnancy is linked to adverse maternal and child health outcomes that are...
-
Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids
Nuclear receptors (NRs) are key regulators of energy homeostasis, body development, and sexual reproduction. Xenobiotics binding to NRs may disrupt...
-
Foreign Compounds: Foods, Drugs, and Other Chemicals
Xenobiotics that humans are exposed through ingestion or inhalation include foods, drugs, smoke, household products, and environmental chemicals....