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Technologies to Study Genetics and Molecular Pathways
Over the last few decades, the study of congenital heart disease (CHD) has benefited from various model systems and the development of molecular...
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Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
We report a genome-wide association study of venous thromboembolism (VTE) incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts....
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Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma: implications for prognosis, immune infiltration, and therapeutic strategies
BackgroundDisulfidptosis and the disulfidptosis-related gene SLC7A11 have recently attracted significant attention for their role in tumorigenesis...
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Identifying latent genetic interactions in genome-wide association studies using multiple traits
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are...
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Identifying the role of transient receptor potential channels (TRPs) in kidney renal clear cell carcinoma and their potential therapeutic significances using genomic and transcriptome analyses
Kidney renal clear cell carcinoma (KIRC) is among the major causes of cancer-caused mortality around the world. Transient receptor potential channels...
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Radiotherapy interruption due to holidays adversely affects the survival of patients with nasopharyngeal carcinoma: a joint analysis based on large-scale retrospective data and clinical trials
BackgroundThe impact of radiotherapy interruption due to the Spring Festival holidays in China on the survival of patients with nasopharyngeal...
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Opportunities for personalizing colorectal cancer care: an analysis of SEER-medicare data
United States clinical practice guidelines for metastatic colorectal cancer recommend use of medications impacted by genetic variants but do not...
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Statins as a risk factor for diabetic retinopathy: a Mendelian randomization and cross-sectional observational study
BackgroundDiabetic retinopathy (DR) is the foremost cause of vision loss among the global working-age population, and statins are among the most...
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Portraying the dark side of endogenous IFN-λ for promoting cancer progression and immunoevasion in pan-cancer
BackgroundIFN-λ has been shown to have a dual function in cancer, with its tumor-suppressive roles being well-established. However, the potential...
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Associations between polygenic risk score and covid-19 susceptibility and severity across ethnic groups: UK Biobank analysis
BackgroundCOVID-19 manifests with huge heterogeneity in susceptibility and severity outcomes. UK Black Asian and Minority Ethnic (BAME) groups have...
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Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders
Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear....
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Age at first exposure to antibiotics and neurodevelopmental outcomes in childhood
RationaleViral illnesses in children are common and are frequently treated with antibiotic medication. Antibiotics reduce the diversity and...
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Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes
BackgroundBlood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and...
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Smoking, alcohol consumption and risk of Dupuytren’s disease: a Mendelian randomization study
BackgroundThe correlation between smoking and alcohol consumption and the development of Dupuytren’s disease (DD) has been acknowledged. However, the...
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Metabolic subtypes and immune landscapes in esophageal squamous cell carcinoma: prognostic implications and potential for personalized therapies
BackgroundThis study aimed to identify metabolic subtypes in ESCA, explore their relationship with immune landscapes, and establish a metabolic index...
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An evaluation of a Stenotrophomonas maltophilia outbreak due to commercial arterial blood gas collection kit
BackgroundStenotrophomonas maltophilia is a gram-negative bacterium that can cause hospital infections and outbreaks within hospitals. This study...
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Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score
BackgroundThe popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder...
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A novel prognostic model based on single-cell RNA sequencing data for hepatocellular carcinoma
BackgroundThe tumour heterogeneous make-up of immune cell infiltrates is a key factor for the therapy response and prognosis of hepatocellular...
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Integrative analysis of prognostic long non-coding RNAs with copy number variation in bladder cancer
Copy number variations (CNVs), which can affect the role of long non-coding RNAs (lncRNAs), are important genetic changes seen in some malignant...
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Inequalities in cancer screening participation between adults with and without severe mental illness: results from a cross-sectional analysis of primary care data on English Screening Programmes
BackgroundPeople with severe mental illness (SMI) are 2.5 times more likely to die prematurely from cancer in England. Lower participation in...