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STK16 promoted colorectal cancer progress in a c-MYC signaling-dependent manner
BackgroundColorectal cancer standed as a global health challenge, ranking third in cancer incidence and second in cancer-related deaths worldwide. A...
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CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment
CLEC16A is a membrane-associated C-type lectin protein that functions as a E3-ubiquitin ligase. CLEC16A regulates autophagy and mitophagy, and...
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Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
Cancer cells establish replicative immortality by activating a telomere-maintenance mechanism (TMM), be it telomerase or the alternative lengthening...
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Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro
Deubiquitinating protease USP7 is a promising therapeutic target for cancer treatment, and interest in develo** USP7 inhibitors has greatly...
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Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy
Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-mediated lipid peroxidation accumulation....
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USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway
Ubiquitin-specific protease 22 (USP22) expression was reported to be increased in response to ischemic brain damage, but the biological role and...
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Molecular therapy of cardiac ischemia–reperfusion injury based on mitochondria and ferroptosis
Excessive death of myocardial cells can lead to various cardiovascular diseases and even develop into heart failure, so develo** ideal treatment...
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Deubiquitylating enzymes: potential target in autoimmune diseases
The ubiquitin–proteasome pathway is responsible for the turnover of different cellular proteins, such as transport proteins, presentation of antigens...
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Mechanisms of Cancer Resistance to Various Therapies
Cancer therapy has witnessed remarkable advancements in eradicating cancer cells within the body, leading to improved patient outcomes and prolonged...
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The Ubiquitin–Proteasome System and Cerebellar Developmental Disease
A variety of developmental diseases of the cerebellum are associated with the dysregulation of proteins regulated by the ubiquitin–proteasome system...
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Phenethyl isothiocyanate inhibits metastasis potential of non-small cell lung cancer cells through FTO mediated TLE1 m6A modification
N6-methyladenosine (m 6 A) modification is a prevalent RNA epigenetic modification, which plays a crucial role in tumor progression including...
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CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis
BackgroundThe repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance,...
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Biological roles of the RNA m6A modification and its implications in cancer
The N 6 -Methyladenosine (m 6 A) modification of RNA transcripts is the most prevalent and abundant internal modification in eukaryotic messenger RNAs...
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Estrogen prevents cellular senescence and bone loss through Usp10-dependent p53 degradation in osteocytes and osteoblasts: the role of estrogen in bone cell senescence
Estrogens play multiple roles in maintaining skeletal homeostasis by regulating many physiological processes in bone cells. Recently, cellular...
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Oxygen Level Modifies the Expression of Genes Involved in the Epigenetic Regulation of Multipotent Stromal Cells In Vitro
Changes in the transcriptional activity of genes involved in the epigenetic regulation of adipose tissue multipotent mesenchymal stromal cells were...
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Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics
Eriocalyxin B (EB), 17-hydroxy-jolkinolide B (HJB), parthenolide (PN), xanthatin (XT) and andrographolide (AG) are terpenoid natural products with a...
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The emerging role of CARM1 in cancer
Coactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a...
