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Colonization and Persistence Strategies of Staphylococcus aureus
S. aureus is a prime example of a multitalented opportunistic pathogen that possesses a broad array of virulence factors, not infrequently redundant...
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Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell growth, apoptosis, senescence, and migration and its...
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Comparative genomic and transcriptomic analyses of transposable elements in polychaetous annelids highlight LTR retrotransposon diversity and evolution
BackgroundWith the expansion of high throughput sequencing, we now have access to a larger number of genome-wide studies analyzing the Transposable...
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The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation
Atrial fibrillation (AF) is the most frequent arrhythmia in adults. The prevalence and incidence of AF is going to increase substantially over the...
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Bacterial Adhesion, Virulence, and Biofilm Formation
The adhesion of bacteria to implanted biomaterial and human tissue surfaces is the first and essential step in the pathogenesis of infection....
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First-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study
BackgroundTherapeutic options are limited in patients with unresectable metastatic colorectal cancer (mCRC) ineligible for intensive chemotherapy....
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The importance of being CAFs (in cancer resistance to targeted therapies)
In the last two decades, clinical oncology has been revolutionized by the advent of targeted drugs. However, the efficacy of these therapies is...
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The trace aminergic system: a gender-sensitive therapeutic target for IBS?
Due to a lack of specific or sensitive biomarkers, drug discovery advances have been limited for individuals suffering from irritable bowel syndrome...
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A bibliometric analysis of the application of the PI3K-AKT-mTOR signaling pathway in cancer
PI3K-AKT-mTOR plays as important role in the growth, metabolism, proliferation, and migration of cancer cells, and in apoptosis, autophagy,...
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Response rate of anticancer drugs approved by the Food and Drug Administration based on a single-arm trial
BackgroundIn recent years, an increasing number of anticancer drugs have been approved based on the results of a single-arm trial (SAT). The...
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Phages are unrecognized players in the ecology of the oral pathogen Porphyromonas gingivalis
BackgroundPorphyromonas gingivalis (hereafter “ Pg ”) is an oral pathogen that has been hypothesized to act as a keystone driver of inflammation and...
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Identifying the tumor location-associated candidate genes in development of new drugs for colorectal cancer using machine-learning-based approach
Numerous studies have been conducted to elucidate the relation of tumor proximity to cancer prognosis and treatment efficacy in colorectal cancer....
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Combining serum inflammation indexes at baseline and post treatment could predict pathological efficacy to anti‑PD‑1 combined with neoadjuvant chemotherapy in esophageal squamous cell carcinoma
BackgroundThe neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic...
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Recent advances in targeted drug delivery systems for resistant colorectal cancer
Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to...
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Chemotherapy induced neutropenia at 1-month mark is a predictor of overall survival in patients receiving TAS-102 for refractory metastatic colorectal cancer: a cohort study
BackgroundTAS-102 (trifluridine and tipiracil hydrochloride; a novel combination oral nucleoside anti-tumor agent) has recently received regulatory...
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A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer
BackgroundPatients with chemotherapy refractory metastatic colorectal cancer (CRC) have a poor prognosis and limited therapeutic options. In this...
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Role of Oxidative Stress in the Occurrence and Development of Cognitive Dysfunction in Patients with Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSAS) causes recurrent apnea and intermittent hypoxia at night, leading to several complications such as cognitive...
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Biosensing Technologies for Detection of Extracellular Vesicles
Extracellular vesicles (EVs) are novel biomarkers evaluated during liquid biopsy and are involved in many physiological functions in cells as well as...
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Mechanistic Exploration and Therapeutic Management of Colon Cancer Metastasis
The metastasis of colon cancer is the leading cause of death in patients with colon cancer. Surgery and chemotherapy have long been the first choices...
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Is the Putative Mirror Neuron System Associated with Empathy? A Systematic Review and Meta-Analysis
Theoretical perspectives suggest that the mirror neuron system (MNS) is an important neurobiological contributor to empathy, yet empirical support is...
