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The neuropeptide calcitonin gene-related peptide links perineural invasion with lymph node metastasis in oral squamous cell carcinoma
ObjectiveAlthough perineural invasion (PNI) is well-known to be correlated with and able to predict lymph node metastasis (LNM) in oral squamous cell...
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Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis
BackgroundRadiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of...
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Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer
BackgroundLymph node metastasis is more likely in early-stage breast cancer with lower tumor-infiltrating lymphocyte (TIL) density. Therefore, we...
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Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment
In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We...
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Rethinking surgical revisions: impact of the MonarchE trial on axillary dissection in hormone-positive HER2-negative early breast cancer patients potentially eligible for abemaciclib
IntroductionThe MonarchE trial explored the use of abemaciclib, a CDK4/6 inhibitor, as an adjuvant treatment in high-risk early-stage luminal-like...
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Automated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer
Preoperative staging of suspicious axillary lymph nodes (ALNs) allows patients to be triaged to ALN dissection or to sentinel lymph node biopsy...
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Altered lymphatic drainage patterns in re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence
BackgroundThis study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence...
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The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study
Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in...
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Revealing the concealed: A tribute to Donald L. Morton, MD
Donald L. Morton, MD, epitomized one of America’s dream scenarios: a person evolving from the humblest of origins to become an international...
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Favorable locoregional control in clinically node-negative hormone-receptor positive breast cancer with low 21-gene recurrence scores: a single-institution study with 10-year follow-up
BackgroundRecent studies have shown a lower likelihood of locoregional recurrences in patients with a low 21-gene recurrence score (RS). In this...
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Liquid biopsy for monitoring of tumor dormancy and early detection of disease recurrence in solid tumors
Cancer is one of the three leading causes of death worldwide. Even after successful therapy and achieving remission, the risk of relapse often...
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Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer
BackgroundThis preliminary study aimed to examine the feasibility of sentinel lymph node biopsy (SLNB) using contrast-enhanced ultrasound (CEUS) vs....
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A systematic methodology review of fluorescence-guided cancer surgery to inform the development of a core master protocol and outcome set
BackgroundFluorescence-guided precision cancer surgery may improve survival and minimize patient morbidity. Efficient development of promising...
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Minimal Invasive and Individualizing Management of the Axillary Nodes
The status of the axillary lymph nodes is one of the most important prognostic factors for patients with breast cancer. For over 100 years, axillary...
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Map** of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial
BackgroundThe majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to...
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IMNI PRECISION trial protocol: a phase II, open-label, non-inferior randomized controlled trial of tailoring omission of internal mammary node irradiation for early-stage breast cancer
BackgroundSince the publication of MA-20 and EORTC-22922 trials, chest wall (CW)/ whole breast (WB) irradiation + comprehensive regional nodal...
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Management of early-stage triple-negative breast cancer: recommendations of a panel of experts from the Brazilian Society of Mastology
BackgroundTriple-negative breast cancer (TNBC) is a heterogenous subtype involving different patterns of behavior and clinical course, demanding a...
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OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized open label trial
BackgroundConservative surgery followed by breast and nodal irradiation is the standard loco-regional early breast cancer (BC) treatment for patients...
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Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels
Cancer metastasis is the process by which primary cancer cells invade through the lymphatic or blood vessels to distant sites. The molecular...
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Intraoperative electron radiotherapy in early invasive ductal breast cancer: 6-year median follow-up results of a prospective monocentric registry
BackgroundIntraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter...