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SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease
IntroductionThe role of suppressor of cytokine signaling 2 (SOCS2) in Aggregatibacter actinomycetemcomitans ( Aa )-induced alveolar bone loss is...
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Mechanistic Evaluation of miRNAs and Their Targeted Genes in the Pathogenesis and Therapeutics of Parkinson’s Disease
MicroRNA (miRNA) are usually 18–25 nucleotides long non-coding RNA targeting post-transcriptional regulation of genes involved in various biological...
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Transcriptome signatures of host tissue infected with African swine fever virus reveal differential expression of associated oncogenes
African swine fever (ASF) has emerged as a threat to swine production worldwide. Evasion of host immunity by ASF virus (ASFV) is well understood....
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Hydroxysafflor Yellow A and Tenuigenin Exhibit Neuroprotection Effects Against Focal Cerebral Ischemia Via Differential Regulation of JAK2/STAT3 and SOCS3 Signaling Interaction
Numerous natural bioactive compounds extracted from Chinese medicines have been proved to be promising and potent agents in the treatment of ischemic...
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Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease
Janus kinase/signal transduction and transcriptional activator (JAK/STAT) signaling pathway is a transport hub for cytokine secretion and exerts its...
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Molecular mechanisms underlying methotrexate-induced intestinal injury and protective strategies
Methotrexate (MTX) is a folic acid reductase inhibitor that manages various malignancies as well as immune-mediated inflammatory chronic diseases....
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Characterization of alternative splicing events and prognostic signatures in gastric cancer
BackgroundAccumulating evidences indicate that the specific alternative splicing (AS) events are linked to the occurrence and prognosis of gastric...
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Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling
BackgroundType 2 diabetes mellitus (T2DM) and obstructive sleep apnea (OSA) are mutual risk factors, with both conditions inducing cognitive...
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TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1
Cervical cancer (CC) is a malignant tumor primarily caused by the persistent infection with high-risk strains of human papillomavirus. This study...
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Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR
BackgroundThe transmembrane receptor Kremen2 has been reported to participate in the tumorigenesis and metastasis of gastric cancer. However, the...
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Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions
The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) cascade is a pleiotropic pathway that involves...
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Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1
BackgroundAlthough influenza A virus (IAV) employs diverse strategies to evade IFN responses by inhibiting the synthesis of IFN, how IAV regulates...
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Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases
Posttranslational modification of proteins via ubiquitination determines their activation, translocation, dysregulation, or degradation. This process...
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Molecular investigation in individuals with orofacial clefts and microphthalmia-anophthalmia-coloboma spectrum
This study describes genomic findings among individuals with both orofacial clefts (OC) and microphthalmia/anophthalmia/coloboma (MAC) recorded in...
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CRL4 Ubiquitin Pathway and DNA Damage Response
DNA damage occurs in a human cell at an average frequency of 10,000 incidences per day by means of external and internal culprits, damage that...
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Beneficial role of kaempferol and its derivatives from different plant sources on respiratory diseases in experimental models
Respiratory illnesses impose a significant health burden and cause deaths worldwide. Despite many advanced strategies to improve patient outcomes,...
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Rheumatoid arthritis—recent advances in pathogenesis and the anti-inflammatory effect of plant-derived COX inhibitors
The majority of people with autoimmune disorders, including those with rheumatoid arthritis, osteoarthritis, and tendonitis report pain, stiffness,...
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Pathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Alzheimer’s disease (AD) is a common age-related neurodegenerative disease in the central nervous system and is the primary cause of dementia. It is...
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Identifying hub genes of sepsis-associated and hepatic encephalopathies based on bioinformatic analysis—focus on the two common encephalopathies of septic cirrhotic patients in ICU
BackgroundIn the ICU ward, septic cirrhotic patients are susceptible to suffering from sepsis-associated encephalopathy and/or hepatic...
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Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study
BackgroundThis study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling ( SOCS )-3 DNA...
