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Molecular Characterization of Single Circulating Tumor Cells in Breast and Ovarian Cancer
Epithelial ovarian cancer (EOC)Epithelial ovarian cancer (EOC) still has the highest mortality rate of all gynecological malignancies, diagnosed...
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The oncogenic roles and clinical implications of YAP/TAZ in breast cancer
Breast cancer (BC) is the most commonly diagnosed form of cancer and a leading cause of cancer-related deaths among women worldwide. Yes-associated...
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Molecular Mechanisms of Metal-Induced Carcinogenesis
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused...
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A validation study of potential prognostic DNA methylation biomarkers in patients with acute myeloid leukemia using a custom DNA methylation sequencing panel
BackgroundMultiple studies have reported the prognostic impact of DNA methylation changes in acute myeloid leukemia (AML). However, these epigenetic...
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Analysis of genetic biomarkers, polymorphisms in ADME-related genes and their impact on pharmacotherapy for prostate cancer
Prostate cancer (PCa) is a non-cutaneous malignancy in males with wide variation in incidence rates across the globe. It is the second most reported...
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DNA Methylation in Atrial Fibrillation and Its Potential Role in Precision Medicine
Atrial fibrillation (AF), a common arrhythmia, can cause many serious consequences, including stroke and even death. The pathological mechanism of AF...
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Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer
BackgroundReproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We...
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System of Markers Based on the Methylation of a Group of Proapoptotic Genes in Combination with MicroRNA in the Diagnosis of Breast Cancer
Systems of markers for the diagnosis of breast cancer based on DNA methylation of a group of suppressor protein-coding genes, hypermethylated...
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STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
PurposeEsophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of critical cell growth...
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Improved urine DNA methylation panel for early bladder cancer detection
BackgroundBladder cancer is one of the most common malignancies but the corresponding diagnostic methods are either invasive or limited in...
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Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis
Aberrant activation of cardiac fibroblasts is the main cause and character of cardiac fibrosis, and inhibition of cardiac fibrosis becomes a...
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Ependymomas in Children and Adults
EpendymomasEpendymomas account for approximately 5% of all CNS tumors in adults and around 10% in the pediatric population. Contrary to traditional...
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Histone H3K9 methyltransferase SETDB1 overexpression correlates with pediatric high-grade gliomas progression and prognosis
AbstractPediatric high-grade gliomas (pHGGs) are heterogeneous, diffuse, and highly infiltrative tumors with dismal prognosis. Aberrant...
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Genetics of Cancer: Past, Present and Future
Cancer is a disease of aberrant cells which evade the cell cycle checkpoints for proliferation and resists apoptotic signals. A cancer cell is...
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Oncogenic Genomic Changes in Cancer
A common cause of all cancers leads us to a common definition. This definition is mutation. Cancer cells tend to constantly resist irregularity under...
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KAZN as a diagnostic marker in ovarian cancer: a comprehensive analysis based on microarray, mRNA-sequencing, and methylation data
BackgroundOvarian cancer (OC) is among the deadliest malignancies in women and the lack of appropriate markers for early diagnosis leads to poor...
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The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling
Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML). These translocations often occur in critical...
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Field Cancerization: A Malignant Transformation
Mutations in a cell is natural, especially in aging cells. However, among all mutated cells, only a certain subset could clonally expand, leading to...
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Epigenetics and Liquid Biopsy in Oncology: Role in Metastasis and Clinical Utility
The deregulation of epigenetic mechanisms in tumor cells is implicated in multiple steps of cancer development and progression. These epigenetic...
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Development of a prognostic risk model for clear cell renal cell carcinoma by systematic evaluation of DNA methylation markers
BackgroundCurrent risk models for renal cell carcinoma (RCC) based on clinicopathological factors are sub-optimal in accurately identifying high-risk...
