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A next-generation GMMA-based vaccine candidate to fight shigellosis
Shigellosis is a leading cause of diarrheal disease in low-middle-income countries (LMICs). Effective vaccines will help to reduce the disease...
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Development of an anti-tauopathy mucosal vaccine specifically targeting pathologic conformers
Alzheimer’s disease (AD) and related tauopathies are associated with pathological tau protein aggregation, which plays an important role in...
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A scrub typhus vaccine presents a challenging unmet need
Scrub typhus caused by the obligately intracellular bacterium, Orientia tsutsugamushi , is a major cause of life-threatening acute undifferentiated...
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An immunoinformatic approach for develo** a multi-epitope subunit vaccine against Monkeypox virus
An in-silico approach was implemented to develop a multi-epitope subunit vaccine construct against the recent outbreak of the Monkeypox virus. The...
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Gastrointestinal Delivery of an mRNA Vaccine Using Immunostimulatory Polymeric Nanoparticles
mRNA vaccines can be translated into protein antigens, in vivo , to effectively induce humoral and cellular immunity against these proteins. While...
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Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine
Previously, we reported that an ANGPTL3 vaccine is a hopeful therapeutic option against dyslipidemia. In our current study, we assess durability and...
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MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans
In response to the COVID-19 pandemic, multiple vaccines were developed using platforms such as viral vectors and mRNA technology. Here, we report...
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Optimization of an alum-anchored clinical HIV vaccine candidate
In the ongoing effort to develop a vaccine against HIV, vaccine approaches that promote strong germinal center (GC) responses may be critical to...
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Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine
Although licensed vaccines against influenza virus have been successful in reducing pathogen-mediated disease, they have been less effective at...
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Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens
Chemical cross-linking is used to stabilize protein structures with additional benefits of pathogen and toxin inactivation for vaccine use, but its...
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Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types
Formyl peptide receptor-like 1 inhibitor protein (FLIPr) is an immune evasion protein produced by Staphylococcus aureus , and FLIPr is a potential...
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Availability and use of Standards in vaccine development
Reference materials are critical in assay development for calibrating and assessing their suitability. The devasting nature of the COVID-19 pandemic...
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Translational and structural vaccinomics approach to design a multi-epitope vaccine against NOL4 autologous antigen of small cell lung cancer
Small cell lung cancer (SCLC) is one of the most common cancers and it is the sixth common cause for cancer-related deaths. The high plasticity and...
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Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform
Human cytomegalovirus (CMV) is the most common infectious cause of complications post-transplantation, while a CMV vaccine for transplant recipients...
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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial
Programmed cell death protein 1 (PD-1) inhibitors have modest efficacy as a monotherapy in hepatocellular carcinoma (HCC). A personalized therapeutic...
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Interim safety and immunogenicity results from an NDV-based COVID-19 vaccine phase I trial in Mexico
There is still a need for safe, efficient, and low-cost coronavirus disease 2019 (COVID-19) vaccines that can stop transmission of severe acute...
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Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice
The protective efficacies of current licensed vaccines against COVID-19 have significantly reduced as a result of SARS-CoV-2 variants of...
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Q fever immunology: the quest for a safe and effective vaccine
Q fever is an infectious zoonotic disease, caused by the Gram-negative bacterium Coxiella burnetii . Transmission occurs from livestock to humans...
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Immunological factors linked to geographical variation in vaccine responses
Vaccination is one of medicine’s greatest achievements; however, its full potential is hampered by considerable variation in efficacy across...
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Development of a therapeutic vaccine targeting Merkel cell polyomavirus capsid protein VP1 against Merkel cell carcinoma
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with a high mortality rate, while Merkel cell polyomavirus (MCV) has been pointed as...
