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A genome-wide association study of contralateral breast cancer in the Women’s Environmental Cancer and Radiation Epidemiology Study
BackgroundContralateral breast cancer (CBC) is the most common second primary cancer diagnosed in breast cancer survivors, yet the understanding of...
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Associations of gut microbiome with endogenous estrogen levels in healthy postmenopausal women
PurposeThe gut microbiome is a potentially important contributor to endogenous estrogen levels after menopause. In healthy postmenopausal women, we...
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Benign breast disease and breast cancer risk in African women: a case–control study
PurposeTo examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.
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Exploring breast tissue microbial composition and the association with breast cancer risk factors
BackgroundMicrobial dysbiosis has emerged as an important element in the development and progression of various cancers, including breast cancer....
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Histopathological Characteristics: Breast Cancer Subtypes Depending on Receptor Status, Clinical and Pathological Staging of Breast Cancer
Breast cancer (BC) is a clinically heterogeneous disease affecting around 14% female population worldwide with unique histopathological and...
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PROCURE European consensus on breast cancer multigene signatures in early breast cancer management
Breast cancer multigene signatures (BCMS) have changed how patients with early-stage breast cancer (eBC) are managed, as they provide prognostic...
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Anthropometric measures and breast cancer risk among Hispanic women in Puerto Rico
IntroductionIncreased risk of postmenopausal breast cancer associated with anthropometric measures including Body Mass Index (BMI), adult weight...
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Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study
BackgroundThe aim of this study was to gain an increased understanding of the aetiology of breast cancer, by investigating possible associations...
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Multigene profiles to guide the use of neoadjuvant chemotherapy for breast cancer: a Copenhagen Breast Cancer Genomics Study
Estrogen receptor (ER) and human epidermal growth factor 2 (HER2) expression guide the use of neoadjuvant chemotherapy (NACT) in patients with early...
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Association between allostatic load and breast cancer risk: a cohort study
BackgroundAllostatic load (AL) reflects the collective load of chronic stress during lifetime. Previous studies have shown that higher AL is...
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Persistence to extended adjuvant endocrine therapy following Breast Cancer Index (BCI) testing in women with early-stage hormone receptor-positive (HR +) breast cancer
PurposeExtending adjuvant endocrine therapy (ET) beyond the standard 5 years offers added protection against late breast cancer recurrences in women...
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Feasibility of point of care testing for prevention and management of breast cancer therapy associated comorbidities in 6 African countries: short communication
Objective:Obesity and mediators of inflammation have been identified as the most important risk and predictive factors in postmenopausal breast...
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Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women
BackgroundHormones impact breast tissue proliferation. Studies investigating the associations of circulating hormone levels with mammographic breast...
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Associations of dietary patterns with kidney cancer risk, kidney cancer-specific mortality and all-cause mortality among postmenopausal women
BackgroundThe empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) are novel measures of dietary...
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Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
BackgroundSeveral studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined...
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Ten-year distant-recurrence risk prediction in breast cancer by CanAssist Breast (CAB) in Dutch sub-cohort of the randomized TEAM trial
BackgroundHormone receptor (HR)-positive, HER2/neu-negative breast cancers have a sustained risk of recurrence up to 20 years from diagnosis. TEAM...
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Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
BackgroundThe clinical utility of gene signatures in older breast cancer patients remains unclear. We aimed to determine signature prognostic...
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Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic...
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Drug repurposing: a retrospective revolution in breast cancer medicine
Breast cancer is a complex disease involving numerous pathways, making effective treatment quite challenging. Among the current scenario, drug...
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Lasofoxifene as a potential treatment for aromatase inhibitor-resistant ER-positive breast cancer
BackgroundBreast cancers treated with aromatase inhibitors (AIs) can develop AI resistance, which is often driven by estrogen receptor-alpha (ERα/ ESR1...
