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Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1α/NLRP3 signaling following thalamic hemorrhagic stroke
BackgroundCentral post-stroke pain (CPSP) is an intractable and disabling central neuropathic pain that severely affects patients’ lives, well-being,...
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Evolving Stroke Systems of Care: Stroke Diagnosis and Treatment in the Post-Thrombectomy Era
Thrombectomy became the gold-standard treatment of acute ischemic stroke caused by large-vessel occlusions (LVO) in 2015 after five clinical trials...
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Alteration of Glycerophospholipid Metabolism in Hippocampus of Post-stroke Depression Rats
Post-stroke depression (PSD) is the most common mental disorder in stroke survivors. However, its specific pathophysiology remains largely unknown....
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Impairment of the internal forward model and feedback mechanisms for vocal sensorimotor control in post-stroke aphasia: evidence from directional responses to altered auditory feedback
The present study examined opposing and following vocal responses to altered auditory feedback (AAF) to determine how damage to left-hemisphere brain...
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Muscle contributions to pre-swing biomechanical tasks influence swing leg mechanics in individuals post-stroke during walking
BackgroundSuccessful walking requires the execution of the pre-swing biomechanical tasks of body propulsion and leg swing initiation, which are often...
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Post-stroke seizures: risk factors and management after ischemic stroke
Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries. It constitutes a significant...
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The resting-state topological organization damage of language-related brain regions in post-stroke cognitive impairment
The topology of brain networks is the foundation of cognition. We hypothesized that stroke damaged topological organization resulting in cognitive...
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Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests
BackgroundRecent technological advancements present promising opportunities to enhance the frequency and objectivity of functional assessments,...
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Three-phase Enriched Environment Improves Post-stroke Gait Dysfunction via Facilitating Neuronal Plasticity in the Bilateral Sensorimotor Cortex: A Multimodal MRI/PET Analysis in Rats
The three-phase Enriched Environment (EE) paradigm has been shown to promote post-stroke functional improvement, but the neuronal mechanisms are...
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Sleep patterns correlates with the efficacy of tDCS on post-stroke patients with prolonged disorders of consciousness
BackgroundThe subclassification of prolonged disorders of consciousness (DoC) based on sleep patterns is important for the evaluation and treatment...
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Direct AT2R Stimulation Slows Post-stroke Cognitive Decline in the 5XFAD Alzheimer’s Disease Mice
Alzheimer’s disease (AD), currently the single leading cause of death still on the rise, almost always coexists alongside vascular cognitive...
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MicroRNA miR-21 Decreases Post-stroke Brain Damage in Rodents
Due to their role in controlling translation, microRNAs emerged as novel therapeutic targets to modulate post-stroke outcomes. We previously reported...
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Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
BackgroundThe intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue...
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Peripheral blood and urine metabolites and biological functions in post-stroke depression
Post-stroke depression (PSD) is the most common and severe neuropsychiatric complication after stroke. However, the molecular mechanism of PSD is...
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Performing a shortened version of the Action Research Arm Test in immersive virtual reality to assess post-stroke upper limb activity
BackgroundTo plan treatment and measure post-stroke recovery, frequent and time-bounded functional assessments are recommended. With increasing needs...
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Neural correlates of walking post-stroke: neuroimaging insights from the past decade
Walking dysfunction such as slow walking speed and reduced independent mobility are common impairments following stroke. Neural mechanisms of upper...
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LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis
Pyroptosis, a type of programmed cell death illuminated by inflammasomes and active caspases, is implicated in post-stroke inflammation. Our previous...
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Post-stroke hand gesture recognition via one-shot transfer learning using prototypical networks
BackgroundIn-home rehabilitation systems are a promising, potential alternative to conventional therapy for stroke survivors. Unfortunately,...
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Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase I trial
Upper-extremity impairment after stroke remains a major therapeutic challenge and a target of neuromodulation treatment efforts. In this open-label,...
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The time-varying networks of the wrist extension in post-stroke hemiplegic patients
Hemiplegia is a common dysfunction caused by the brain stroke and leads to movement disability. Although the lateralization of movement-related...
