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IMU-based sensor-to-segment multiple calibration for upper limb joint angle measurement—a proof of concept
A lot of attention has been paid to wearable inertial sensors regarded as an alternative solution for outdoor human motion tracking. Relevant joint...
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Systemic Drug Delivery to the Posterior Segment of the Eye: Overcoming Blood–Retinal Barrier Through Smart Drug Design and Nanotechnology
The human eye being a highly privileged organ with complex barriers, reaching the posterior part of the eye via systemic routes, is still a major...
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Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions
The interphotoreceptor matrix (IPM) is the extracellular matrix between the photoreceptors and the retinal pigment epithelium (RPE). The IPM has two...
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B-Map: a fuzzy-based model to detect foreign objects in a brain
To cope up with the medical complications, scientists and physicians rely more on digitized historical evidence. It helps them to identify the...
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Distribution, quantification, and characterization of substance P enteric neurons in the submucosal and myenteric plexuses of the porcine colon
The pig is an important translational model for studying intestinal physiology and disorders for its many homologies with humans, including the...
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Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses
Accumulation of misfolded host proteins is central to neuropathogenesis of numerous human brain diseases including prion and prion-like diseases....
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Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation
The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also called SCG10), is profoundly impacted by TAR DNA-binding protein...
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Concomitant Polymyalgia Rheumatica and Giant Cell Arteritis Associated with Cystic Echinococcosis: A Rare Geriatric Case
IntroductionParasitic infections could be an important triggering factor for autoimmune diseases. We present a clinical case of concomitant...
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The macular inner plexiform layer thickness as an early diagnostic indicator for Parkinson’s disease
Whether structural alterations of intraretinal layers are indicators for the early diagnosis of Parkinson’s disease (PD) remains unclear. We assessed...
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Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disease and the main cause for dementia. The irreversible neurodegeneration leads to a gradual loss...
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Caligus madeirensis sp. nov. (Copepoda: Caligidae) Parasitic on Pompano, Trachinotus ovatus (Linnaeus, 1758), from Eastern Atlantic Waters, Surrounding the Madeira Archipelago, Portugal
IntroductionA new species of the genus Caligus is described based on specimens collected from pompano, Trachinotus ovatus (Linnaeus), caught in...
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Self-Double-Emulsifying Drug Delivery System Enteric-Coated Capsules: A Novel Approach to Improve Oral Bioavailability and Anti-inflammatory Activity of Panax notoginseng Saponins
In this work, self-double-emulsifying drug delivery system enteric-coated capsules (PNS-SDE-ECC) were used to enhance the oral bioavailability and...
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Autophagy in Human Retinal Neurons in Glaucoma
Immunohistochemical and ultrastructural analysis revealed signs of structural alterations in neurons and autophagy in all layers of the human retina...
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Generation of Three-Dimensional Retinal Tissue with Physiologically Competent, Light-Sensitive Photoreceptors from Human-Induced Pluripotent Stem Cells
Human retinal organoids are three-dimensional tissue systems derived from human pluripotent stem cells (hPSCs) that recreate aspects of the...
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On the uncertainty quantification of the active uterine contraction during the second stage of labor simulation
Uterine contractions in the myometrium occur at multiple scales, spanning both organ and cellular levels. This complex biological process plays an...
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Connecting tubules develop from the tip of the ureteric bud in the human kidney
The connecting tubule (CNT) is a unique segment of the nephron connecting the metanephric mesenchyme (MM)-derived distal convoluted tubule (DCT) and...
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Tick-borne pathogens of zoonotic and veterinary importance in cattle ticks in Ghana
Ticks are important vectors involved in the transmission of pathogens of zoonotic and veterinary importance. In this study, ticks were collected from...
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Photoreceptor phosphodiesterase (PDE6): activation and inactivation mechanisms during visual transduction in rods and cones
Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary intracellular messenger for the visual signaling pathway that...
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Two New Genera and Species of the Parasitic Copepod Family Chondracanthidae Milne Edwards, 1840 (Copepoda: Cyclopoida) from Deep-Sea Fishes Off Suruga Bay, Japan
PurposeThe present paper describes two new genera and species of the parasitic copepod family Chondracanthidae Milne Edwards, 1840 based on specimens...
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Genetic Alterations of Tubular Transport of NaCl and Water
A number of disorders of hydrosaline balance originate from mutations with loss or gain of function of transporter, ion channel, or enzyme function...