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Sex differences in the association between plasma polyunsaturated fatty acids levels and moderate-to-severe plaque psoriasis severity: a cross-sectional and longitudinal study
BackgroundPsoriasis is a chronic inflammatory skin disease with metabolic abnormalities serving as important contributors for pathogenesis and...
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Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice
ObjectiveDietary intervention is a practical prevention strategy for age-related hearing loss (AHL). Omega-3 (n-3) polyunsaturated fatty acids...
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Omega-3 fatty acid supplementation can prevent changes in mitochondrial energy metabolism and oxidative stress caused by chronic administration of L-tyrosine in the brain of rats
Deficiency of hepatic enzyme tyrosine aminotransferase characterizes the innate error of autosomal recessive disease Tyrosinemia Type II. Patients...
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Circulating Polyunsaturated Fatty Acids (PUFAs) as Biological Indicators in Trauma
Dietary polyunsaturated fatty acids (PUFAs) play a vital role in cell growth, development, and function, especially in maternal and early child... -
Exercise and Diet in the Control of Inflammation and Pain
Lifestyle choices, such as exercise and diet, can play significant roles in mediating inflammation and consequently, pain. Functional medicine is an... -
Metabolic Approaches to the Treatment of Autism Spectrum Disorders
Children with autism spectrum disorder (ASD) may exhibit metabolic abnormalities, either with or without an underlying inherited metabolic... -
Green-lipped (greenshell™) mussel (Perna canaliculus) extract supplementation in treatment of osteoarthritis: a systematic review
ObjectivesIntervention studies using New Zealand green-lipped or greenshell™ mussel (GSM) ( Perna canaliculus ) extract in osteoarthritis (OA)...
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The effect of vitamin D supplementation on survival in patients with colorectal cancer: systematic review and meta-analysis of randomised controlled trials
BackgroundLow circulating vitamin D levels are associated with poor colorectal cancer (CRC) survival. We assess whether vitamin D supplementation...
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Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells
BackgroundEnvironmental exposures may alter DNA methylation patterns of T helper cells. As T helper cells are instrumental for allergy development,...
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Clinical Application and Trials with Nutraceuticals
Pharmaceutical drugs are chemical compounds that are designed to prevent, diagnose, and treat a specific disorder. Nutraceuticals are products that... -
Long-term effects of adolescent exposure to olanzapine in C57BL/6 J mice and the impact of dietary fish oil supplementation
RationaleSecond-generation antipsychotic (SGA) medications can produce abnormal weight gain and metabolic dysfunction in children, but little is...
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Current Management Options for Patients with Retinitis Pigmentosa
With an estimated prevalence of 1 in 4000 worldwide [1], retinitis pigmentosa (RP) comprises a spectrum of progressive inherited retinal disorders... -
Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?
Uncontrolled inflammation giving rise to excessive tissue inflammation can lead to chronic inflammation that enhances tissue destruction, amplifying...
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Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause
BackgroundThe role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female population is not...
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Role of antioxidative activity in the docosahexaenoic acid’s enteroprotective effect in the indomethacin-induced small intestinal injury model
Therapeutic effect of non-steroidal anti-inflammatory drugs (NSAIDs) has been related with gastrointestinal injury. Docosahexaenoic acid (DHA), an...
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Role of Micronutrients in Neurological Development
Food is an essential component for reinforcing the physical and mental health of an individual. Balanced nutrients are essential for normal body... -
Effect of flaxseed oil supplementation on the erythrocyte membrane fatty acid composition and endocannabinoid system modulation in patients with coronary artery disease: a double-blind randomized controlled trial
BackgroundThe endocannabinoid system (ECS) overactivation, associated with increased inflammatory process, may act as a risk factor for coronary...
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Molecular Mechanism of Brain Aging: Protective Effects of Phytochemicals
Brain aging is an irretrievable process that occurs in the elderly population and inescapable phase of the entity. Aging is associated with complex... -
Probiotic and Dietary Interventions in Alzheimer’s Disease
Alzheimer’s disease (AD), a sickness that results in the degradation of brain cells, leads to various complications including dementia, which is... -
Obesity and efficacy of vitamin D3 supplementation in healthy black adults
PurposeResults from recent clinical trials suggest that vitamin D efficacy against cancer may be influenced by body mass index. As suppression of...