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USP2 Promotes the Proliferation and Inflammation of Fibroblast-Like Synovial Cells in Rheumatoid Arthritis Through Deubiquitination of TRAF2
Rheumatoid arthritis (RA) is a prevalent inflammatory disorder affecting about 1% of the global population. The ubiquitin-specific protease 2 (USP2)...
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Identification of novel protein biomarkers from the blood and urine for the early diagnosis of bladder cancer via proximity extension analysis
BackgroundBladder cancer (BC) is a very common urinary tract malignancy that has a high incidence and lethality. In this study, we identified BC...
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STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats
BackgroundThe purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible...
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Resveratrol and Immunomodulation
Resveratrol is a stilbenoid polyphenolic molecule widely known for its biological properties, which is available in nature in various varieties of...
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Expression of NF-κB-associated lncRNAs in different types of migraine
PurposeNF-κB partakes in the pathophysiology of neurologic conditions. We quantified levels of NF-κB-associated genes in 119 patients with migraine...
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Proteomics: an emerging tool for the discovery of bone mineral density molecular pathways
Osteoporosis is a polygenic disease associated with low bone mineral density and deterioration of bone miniscule architecture and increased chance of...
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Hypoxia-Induced Apoptosis in Cancer Development
According to World Health Organization reports, cancer is the leading cause of mortality, accounting for approximately ten million deaths or 1 in 6...
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Transglutaminase 3 suppresses proliferation and cisplatin resistance of cervical cancer cells by inactivation of the PI3K/AKT pathway
Recent studies have shown that dysregulation of transglutaminase 3 (TGM3) is related to the aggressive progression of several cancer types. Our study...
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Drug Used in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, predominantly affecting the joints, skin, vessels, and the lungs. Non-steroidal...
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Role of Carotenoids on Oxidative Stress–Mediated Signaling in Cancer Cells
Carotenoids are natural pigments that are naturally occurring in green vegetables, fruits, seaweeds, and microorganisms. Carotenoids belong to the...
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Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia–reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway
BackgroundAstrocyte over-activation and extensive neuron loss are the main characteristic pathological features of spinal cord ischemia–reperfusion...
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Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer
Medicinal mushrooms have considerable therapeutic (130 different) properties, including anticancer, antiviral, antibacterial, antiparasitic,...
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Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways
This study aims to investigate the effect of irisin on ethanol-induced behavioral deficits and explore the underlying mechanisms. A mouse model of...
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Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation
BackgroundEfforts to precisely assess tumor-specific T-cell immune responses still face major challenges, and the potential molecular mechanisms...
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Sargahydroquinoic Acid, a Cyclooxygenase-2 Inhibitor, Attenuates Inflammatory Responses by Regulating NF-κB Inactivation and Nrf2 Activation in Lipopolysaccharide-Stimulated Cells
Sargahydroquinoic acid (SHQA) is a major plastoquinone in Sargassum macrocarpum and has shown the capacity to prevent inflammation and oxidative...
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Screening Methods for the Evaluation of Antiglaucoma and Anticataract Drugs
Glaucoma and cataract are the most common ophthalmic conditions that can lead to visual impairment and eventually blindness, if untreated. Visual...
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Risk factors for antibiotic resistance and mortality in patients with bloodstream infection of Escherichia coli
This study aimed to investigate the risk factors for bloodstream infection (BSI) caused by extended-spectrum beta-lactamase (ESBL)–producing Escherichi...
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Genes and Pathways Involved in the Progression of Malignant Pleural Mesothelioma: A Meta-analysis of Genome-Wide Expression Studies
Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural tissue that lines the lungs and is mainly associated with long...
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Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a murine model of perimenopausal depression
RationaleNeuroinflammation can be alleviated via M2 microglia polarization, which could promote the recovery of perimenopausal depression. Astragalin...
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The Role of JNK3 in Epilepsy and Neurodegeneration
N-terminal kinases (JNKs) belong to the subfamily of mitogen-activated protein kinases (MAPKs). JNKs are considered central signal transducers in the...