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1. Glutamine Supplementation Attenuates the Inflammation Caused by LPS-Induced Acute Lung Injury in Mice by Regulating the TLR4/MAPK Signaling Pathway

   Bacterial infection is one of the main causes of bovine respiratory disease (BRD), which can cause tremendous losses for the herd farming industry...

   Jie Huang, **g Liu, ... **angzhen Shen in Inflammation

   Article 23 June 2021
   

2. A comparative study of IL-33 and its receptor ST2 in a C57BL/6 J mouse model of pulmonary Cryptococcus neoformans infection

   It has been reported that IL-33 receptor ST2 deficiency mitigates Cryptococcus neoformans ( C. neoformans ) pulmonary infection in BALB/c mice. IL-33...

   Zhengxia Wang, Qiyun Ma, ... Mingshun Zhang in Medical Microbiology and Immunology

   Article 11 November 2022
   

3. Pylorus ligation-induced hyperacidity: synergistic prophylactic effects of linagliptin and L-arginine via up-regulation of EP4 receptor subtype and improvement of vascular endothelial damage

   Gastric hyperacidity and ulceration are chronic diseases characterized by repeated healing followed by re-exacerbation. The study aims to protect...

   Gihan F. Asaad, Dalia O. Saleh, ... Gehad Abdel Jaleel in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article Open access 24 August 2023
   

4. Bicarbonate transport of airway surface epithelia in luminally perfused mice bronchioles

   HCO ₃ ⁻ secretion in distal airways is critical for airway mucosal defense. HCO ₃ ⁻ /H ⁺ transport across the apical membrane of airway surface epithelial...

   Libin Liu, Akiko Yamamoto, ... Hiroshi Ishiguro in The Journal of Physiological Sciences

   Article Open access 23 February 2022
   

5. Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

   Most animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus....

   Atousa Moghadam Fard, Pardis Goodarzi, ... Bahman Yousefi in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 15 February 2024
   

6. Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A)

   Various human tissues express the calcium-activated chloride channel Anoctamin 1 (ANO1), also known as TMEM16A. ANO1 allows the passive chloride flux...

   Jorge Arreola, Patricia Pérez-Cornejo, ... María Luisa Guzmán-Hernández in Anion Channels and Transporters

   Chapter 2022
   

7. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity

   Goblet cells secrete mucin to create a protective mucus layer against invasive bacterial infection and are therefore essential for maintaining...

   Hassan Melhem, Berna Kaya, ... Jan Hendrik Niess in Mucosal Immunology

   Article Open access 09 March 2022
   

8. Validation of TMEM16A Modulation as a Therapeutic Approach for the Treatment of Cystic Fibrosis: The Discovery of Novel TMEM16A Potentiators

   The discovery of transmembrane member 16A (TMEM16A) as the molecular identity of Ca 2+-activated Cl− channels (CaCCs) has reignited interest in the...

   Henry Danahay, Martin Gosling in Ion Channels as Targets in Drug Discovery

   Chapter 2024
   

9. Oxidative stress and ROS-mediated cellular events in RSV infection: potential protective roles of antioxidants

   Respiratory syncytial virus (RSV), a member of the Pneumoviridae family, can cause severe acute lower respiratory tract infection in infants, young...

   Xue Yang, Xue Liu, ... Bin Zhu in Virology Journal

   Article Open access 05 October 2023
   

10. Mucopenetrating Janus Nanoparticles For Field-Coverage Oral Cancer Chemoprevention

    Introduction

    Oral squamous cell carcinoma (OSCC), is associated with high morbidity and mortality. Preemptive interventions have been postulated to...

    Nahal Habibi, Caroline Bissonnette, ... Susan R. Mallery in Pharmaceutical Research

    Article Open access 12 January 2023
    

11. Gamma-delta T cells modulate the microbiota and fecal micro-RNAs to maintain mucosal tolerance

    Background

    Gamma-delta (γδ) T cells are a major cell population in the intestinal mucosa and are key mediators of mucosal tolerance and microbiota...

    Rafael M. Rezende, Laura M. Cox, ... Howard L. Weiner in Microbiome

    Article Open access 23 February 2023
    

12. Lectures 7 and 8: Digestive System

    Digestion (disassembly) is necessary to reduce the very large molecules (polymers) ingested as food to particles small enough to pass into the cells...

    Martin Caon in Lecture Notes, Worksheets, and Exercises for Basic Anatomy and Physiology

    Chapter 2024
    

13. The development of a 3D-printed in vitro integrated oro-pharyngeal air–liquid interface cellular throat model for drug transport

    To simulate the deposition of drugs in the oro-pharynx region, several in vitro models are available such as the United States Pharmacopeia-Induction...

    Zara Sheikh, Antonella Granata, ... Daniela Traini in Drug Delivery and Translational Research

    Article 14 February 2023
    

14. PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma

    Abstract

    Asthma is an inflammatory airway disease wherein bronchoconstriction, airway inflammation, and airway obstruction during asthma attacks are...

    Baowei Ma, Seyyed Shamsadin Athari, ... Limin Zhao in Inflammation

    Article 16 April 2021
    

15. Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

    Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased...

    Zhi-lun Yu, Rui-yang Gao, ... Wei Dou in Acta Pharmacologica Sinica

    Article Open access 15 March 2024
    

16. Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical-induced toxicity

    Intestinal organoid may serve as an alternative model for toxicity testing. However, the linkage between specific morphological alterations in...

    Ziwei Wang, Shen Chen, ... Wen Chen in Archives of Toxicology

    Article 20 February 2023
    

17. Macrolides and Cystic Fibrosis

    Macrolide antibiotics attracted interest as a potential therapy in cystic fibrosis (CF) due to remarkable similarities in pathogenic features with...

    Rishi Pabary, Adam Jaffe, Andrew Bush in Macrolides as Immunomodulatory Agents

    Chapter 2024
    

18. Forensic Serology

    Biological evidences, e.g. blood, semen, vaginal secretion, saliva, urine, and sweat encountered at the crime scene, are the most pervasive in...

    Manisha Rana, Pankaj Shrivastava, ... R. K. Kumawat in Textbook of Forensic Science

    Chapter 2023
    

19. Secretin: a hormone for HCO₃⁻ homeostasis

    Secretin is a key hormone of the intestinal phase of digestion which activates pancreatic, bile duct and Brunner gland HCO ₃ ⁻ secretion. Recently, the...

    Peder Berg, Samuel L. Svendsen, ... Jens Leipziger in Pflügers Archiv - European Journal of Physiology

    Article 15 January 2024
    

20. Transport properties in CFTR−/− knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na⁺ absorption

    Previous analysis of CFTR-knockout (CFTR−/−) in piglets has provided important insights into the pathology of cystic fibrosis. However, controversies...

    Roberta Benedetto, Raquel Centeio, ... Karl Kunzelmann in Pflügers Archiv - European Journal of Physiology

    Article Open access 25 July 2020