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Diagnostic potential of exosomal extracellular vesicles in oncology
Liquid biopsy can detect circulating cancer cells or tumor cell-derived DNA at various stages of cancer. The fluid from these biopsies contains...
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Insights into the Oxidative Stress and microRNA-Based Therapeutics in Colorectal Cancer
Colorectal cancer (CRC) is the most common cancer leading to cancer associated death and heavy societal burden. The risk for CRC is linked with...
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Insights into the Oxidative Stress and microRNA-Based Therapeutics in Colorectal Cancer
Colorectal cancer (CRC) is the most common cancer leading to cancer associated death and heavy societal burden. The risk for CRC is linked with...
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Co-regulation of circadian clock genes and microRNAs in bone metabolism
Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone...
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Functional genetic variants of GEN1 predict overall survival of Chinese epithelial ovarian cancer patients
BackgroundInherited variations in DNA double-strand break (DSB) repair pathway are known to influence ovarian cancer occurrence, progression and...
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Circulating exosomal microRNAs as potential prognostic biomarkers in gastrointestinal cancers: a systematic review and meta-analysis
BackgroundRecent reports suggested that circulating exosomal microRNAs (exomiRs) may serve as non-invasive prediction biomarkers in gastrointestinal...
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The function and mechanisms of action of circular RNAs in Urologic Cancer
Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs...
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Specific expression profile of follicular fluid-derived exosomal microRNAs in patients with diminished ovarian reserve
BackgroundDiminished ovarian reserve (DOR) is defined as a reduction in ovarian reserve and oocyte quality. The pathophysiology of DOR has not been...
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Food XenomiRNA Arise: MicroRNA Storm and Space
MicroRNAs (miRNAs) are mobile and protein noncoding genes. Therefore, miRNA genes are informational. RNA informational genes (Rigs) can regulate most...
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Translational Opportunities of Extracellular Vesicles in Biomedicine
Extracellular vesicles are nanoscaled particles continuously released by cells, reflecting their phenotype in their membrane and within their load....
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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and...
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FBXW7 in breast cancer: mechanism of action and therapeutic potential
Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat...
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MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with...
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Overexpression of Circ_0005585 Alleviates Cerebral Ischemia Reperfusion Injury via Targeting MiR-16-5p
Circular RNAs are implicated in the pathogenesis of ischemic stroke. In this work, we explored the modulation and potential mechanisms of action of...
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Role of MicroRNA in ROS Modulation and Its Implication in Lung Cancer and Therapeutics
microRNA are 21–22 nucleotide long single-stranded RNA that has gained a considerable reputation as a potential biomarker in tumorigenesis. Previous...
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NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation
Atherosclerosis (AS) is a chronic inflammatory disease with thickening or hardening of the arteries, which led to the built-up of plaques in the...
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Alterations of plasma circulating microRNAs in BALB/c mice with Toxocara canis visceral and cerebral larva migrans
BackgroundHuman toxocariasis is a neglected parasitic disease characterised by the syndromes visceral, cerebral, and ocular larva migrans. This...
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MicroRNA-34 and gastrointestinal cancers: a player with big functions
It is commonly assumed that gastrointestinal cancer is the most common form of cancer across the globe and is the leading contributor to...
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Role of MicroRNA in ROS Modulation and Its Implication in Lung Cancer and Therapeutics
microRNA are 21–22 nucleotide long single-stranded RNA that has gained a considerable reputation as a potential biomarker in tumorigenesis. Previous...
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Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma
BackgroundDistinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence of reliable biomarkers. Circulating...
