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Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis
BackgroundHyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized...
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The promoting effect and mechanism of Nrf2 on cell metastasis in cervical cancer
BackgroundCervical cancer (CC) has poor prognosis and high mortality rate for its metastasis during the disease progression. Epithelial-mesenchymal...
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Neural Influence on Cancer Invasion and Metastasis
Nerves modulate the surrounding tissue to facilitate nerve repair and regeneration. This fascinating regenerative ability is demonstrated in case of...
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Tumor Associated Neutrophils (TANs) and Cancer Metastasis
Neutrophils play an important role in human innate immunity, but their role in cancer biology was underestimated. It was seen that a high...
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Prognosticating Drug Targets and Responses by Analyzing Metastasis-Related Cancer Pathways
Cancer is a chronologic disease characterized by abnormal cellular proliferation and the potential to spread to other parts of the body. Activating...
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Lymphovascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis
The number of genetic mutations that cause lymphedema and other diseases of the lymphatic system has significantly grown in recent years. This...
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Tumor microenvironment in ovarian cancer peritoneal metastasis
Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common...
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Immune Cell Trafficking in the Lymphatics, Hyaluronan Biology and Tumour Metastasis
As an integral part of the immune system, the lymphatics enable immune surveillance by shepherding the migration of antigen-laden immune cells to...
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Urologic Cancer and the First Patterns of Metastasis
In this chapter we will describe the patterns of metastasis for two of the most common genitourinary malignancies, prostate cancer and bladder...
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Cancer Metastasis: Dynamic Hetero-cellular Communications Between Cancer Cells and Host Tissues
Metastasis is the most devastating aspect of cancer. Originally, tumor cells arise from a single clone, and then they undergo additional mutations...
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Engineered Nanoscale Lipid-Based Formulation as Potential Enhancer of Gefitinib Lymphatic Delivery: Cytotoxicity and Apoptotic Studies Against the A549 Cell Line
The present study aimed to engineer a nanoscale lipid-based lymphatic drug delivery system with D-α-Tocopherol polyethylene glycol 1000 succinate to...
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Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancer
Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity between primary and metastatic breast cancer, and more...
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Biomarkers in Tumor Recurrence and Metastasis
Biomolecules that are produced or secreted by tumor cells themselves or in response to tumor by other cells of body are cancer biomarkers that...
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Association of the pathomics-collagen signature with lymph node metastasis in colorectal cancer: a retrospective multicenter study
BackgroundLymph node metastasis (LNM) is a prognostic biomarker and affects therapeutic selection in colorectal cancer (CRC). Current evaluation...
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The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely related in the process of...
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Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of...
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Role of stromal PD-L1 expression in colorectal liver metastasis
Background and AimThe outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of...
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Characterization of surface markers on extracellular vesicles isolated from lymphatic exudate from patients with breast cancer
BackgroundBreast cancer is the most common cancer, and the leading cause of cancer-related deaths, among females world-wide. Recent research suggests...
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Clinical implications of micro lymph node metastasis for patients with gastric cancer
BackgroundLymph node size is considered as a criterion for possible lymph node metastasis in imageology. Micro lymph nodes are easily overlooked by...
