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Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively
Eomesodermin (Eomes) is a critical factor in the development of natural killer (NK) cells, but its precise role in temporal and spatial coordination...
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Point of Care Molecular Diagnostics in Cancer
Among the major challenges facing the clinical applications of point of care (PoC) devices is to enable rapid, accurate, convenient, and...
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Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes
Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here,...
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lncRNA SNHG9 enhances liver cancer stem cell self-renewal and tumorigenicity by negatively regulating PTEN expression via recruiting EZH2
Liver cancer stem cell (CSC) self-renewal and tumorigenesis are important causes of hepatocellular carcinoma (HCC) recurrence. We purposed to...
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Genome-wide RNA polymerase stalling shapes the transcriptome during aging
Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined...
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Transcriptome and proteome analysis reveals the anti-cancer properties of Hypnea musciformis marine macroalga extract in liver and intestinal cancer cells
BackgroundMarine seaweeds are considered as a rich source of health-promoting compounds by the food and pharmaceutical industry. Hypnea musciformis ...
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Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
Lymphocyte activation gene 3 (LAG3), an immune checkpoint molecule expressed on activated T cells, functions as a negative regulator of immune...
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Primate-specific ZNF808 is essential for pancreatic development in humans
Identifying genes linked to extreme phenotypes in humans has the potential to highlight biological processes not shared with all other mammals. Here,...
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Dietary diosgenin transcriptionally down-regulated intestinal NPC1L1 expression to prevent cholesterol gallstone formation in mice
BackgroundCholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we...
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An Introduction to Safety Toxicology
To simply define the breadth and depth of knowledge that is encompassed by the discipline of toxicology is a very difficult task and is no easier...
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ZNF148 inhibits HBV replication by downregulating RXRα transcription
BackgroundProgressive hepatitis B virus (HBV) infection can result in cirrhosis, hepatocellular cancer, and chronic hepatitis. While antiviral drugs...
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Microfluidics for Food and Nutrition Applications
Fluid flow at the micro- and nanoscale exhibits unique phenomena that can be used to create components suitable for conducting biological studies....
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The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC
Accumulating evidence indicated that HHEX participated in the initiation and development of several cancers, but the potential roles and mechanisms...
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Vascularized tumor models for the evaluation of drug delivery systems: a paradigm shift
As the conversion rate of preclinical studies for cancer treatment is low, user-friendly models that mimic the pathological microenvironment and drug...
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Mammalian Cell Culture in Three Dimensions: Basic Guidelines
Mammalian cell culture has technologically advanced from being conducted in two- to three-dimensional culture vessels (2D and 3D, respectively). The...
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HBXIP induces PARP1 via WTAP-mediated m6A modification and CEBPA-activated transcription in cisplatin resistance to hepatoma
Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA-binding protein that is involved in various biological functions, including DNA damage repair and...
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The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression
Drug-induced liver injury (DILI) is a major cause of acute liver failure and drug withdrawal. Cytochrome P450 (CYP) 2E1 is involved in the metabolism...
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In vitro toxicology: Next generation models and methods to improve safety evaluation
With the advent of molecular and cellular toxicology, the field of drug safety evaluation has been undergoing an important paradigm shift, which has...
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NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells
The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, the mechanisms...
