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Task parameters influence operant response variability in mice
RationaleDuring operant conditioning, animals associate actions with outcomes. However, patterns and rates of operant responding change over...
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Using Gait Variability to Predict Inter-individual Differences in Learning Rate of a Novel Obstacle Course
This study aimed to determine whether inter-individual differences in learning rate of a novel motor task could be predicted by movement variability...
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Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1
BackgroundFollowing solid organ transplantation, tacrolimus (TAC) is an essential drug in the immunosuppressive strategy. Its use constitutes a...
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Capturing cognitive and behavioral variability among individuals with Down syndrome: a latent profile analysis
BackgroundThere is a high degree of inter- and intra-individual variability observed within the phenotype of Down syndrome. The Down Syndrome...
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Investigation of baseline attention, executive control, and performance variability in female varsity athletes
To examine attention, executive control, and performance variability in healthy varsity athletes and identify unique resting-state functional...
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A population pharmacokinetic model for individualized regimens of finasteride according to CYP3A5 genotype and liver function
PurposeFinasteride, a 5α-reductase inhibitor, is used in clinical practice to treat benign prostatic hyperplasia and androgenetic alopecia. However,...
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Sensor Data from Wearable Technologies to Inform Decision-Making to Individualize Training Procedures of Athletes
To attain competitive advantage, athletes need to make decisions to optimize their training procedures. Due to inter- and intra-individual...
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The individuality index: a measure to quantify the degree of inter-individual, spatial variability in intra-cerebral brain electric and metabolic activity
Contemporary neuroscience research primarily focuses on the identification of brain activation patterns commonly deviant across participant groups or...
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How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study
The circadian rhythm of cardiac electrophysiology is dependent on many physiological and biochemical factors. Provided, that models describing the...
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Pharmacogenomics: current status and future perspectives
Inter-individual variability in drug response, be it efficacy or safety, is common and likely to become an increasing problem globally given the...
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The method for assessment of local permutations in the glomerular patterns of the rat olfactory bulb by aligning interindividual odor maps
The comparison of odor functional maps in rodents demonstrates a high degree of inter-individual variability in glomerular activity patterns. There...
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Ring Chromosome 18
Although it is ultra-rare, ring chromosome 18 (RC18) is one of the most commonly occurring congenital ring chromosomes (RCs). This is likely due to...
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Variability in Human In Vitro Enzyme Kinetics
There are many factors which are known to cause variability in human in vitro enzyme kinetic data. Factors such as the source of enzyme and how it...
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Overnight slee** heart rate variability of Army recruits during a 12-week basic military training course
PurposeThis study aimed to quantify slee** heart rate (HR) and HR variability (HRV) alongside circulating tumor necrosis factor alpha (TNFα)...
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Conventional methods to prescribe exercise intensity are ineffective for exhaustive interval training
PurposeTo compare methods of relative intensity prescription for their ability to normalise performance (i.e., time to exhaustion), physiological,...
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Reinforcement Motor Learning After Cerebellar Damage Is Related to State Estimation
Recent work showed that individuals with cerebellar degeneration could leverage intact reinforcement learning (RL) to alter their movement. However,...
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Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells
BackgroundCultured human red blood cells (RBCs) provide a powerful ex vivo assay platform to study blood-stage malaria infection and propagation. In...
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Automated analysis of finger blood pressure recordings provides insight in determinants of baroreflex sensitivity and heart rate variability—the HELIUS study
Sympathovagal balance is important in the pathogenesis of hypertension and independently associated with mortality. We evaluated the value of...
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Resolving molecular contributions of ion channel noise to interspike interval variability through stochastic shielding
Molecular fluctuations can lead to macroscopically observable effects. The random gating of ion channels in the membrane of a nerve cell provides an...
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Coordination Variability During Walking and Running in Individuals With and Without Patellofemoral Pain Part 2: Proximal Segments Coordination Variability
PurposeThere is a scarcity of studies evaluating the variability of couplings between proximal segments (trunk, pelvis, and thigh) in individuals...
