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A Pharmacokinetic, Safety, and Tolerability Trial of Palovarotene in Healthy Japanese and Non-Japanese Participants
Background and ObjectivePalovarotene is an oral, selective retinoic acid receptor gamma agonist under investigation for fibrodysplasia ossificans...
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The promise of precision medicine in rheumatology
Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in clinical presentation, disease course, and treatment response....
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Markers of endothelial glycocalyx dysfunction in Clarkson disease
BackgroundClarkson disease (monoclonal gammopathy-associated idiopathic systemic capillary leak syndrome, ISCLS) is a rare idiopathic condition...
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COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report
BackgroundThe CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety...
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Viral Vector-Induced Ocular Hypertension in Mice
Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible...
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Stereotactic body radiation therapy for the treatment of localized prostate cancer in men with underlying inflammatory bowel disease
BackgroundHistorically, IBD has been thought to increase the underlying risk of radiation related toxicity in the treatment of prostate cancer. In...
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Rheumatoid arthritis-associated complications during pregnancy and its effect on offspring: comprehensive review
This study comprehensively explores the complexities of rheumatoid arthritis during pregnancy and its impact on offspring. Through an extensive...
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The prognostic value of IgA anti-citrullinated protein antibodies and rheumatoid factor in an early arthritis population with a treat-to-target approach
The mucosal origin hypothesis of rheumatoid arthritis has renewed the interest in IgA autoantibodies, but their added value over IgG...
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Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis?
Objective and designA cross-sectional single-center study was conducted to assess cytokine levels in aqueous humor (AH) and plasma of three different...
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Targeting IL-36 in Inflammatory Skin Diseases
Interleukin (IL)-36 cytokines are members of the IL-1 superfamily of cytokines. IL-36 cytokines are composed of three agonists (IL-36α, IL-36β, and...
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Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural, inflammatory, and metabolic changes that fluctuate in a...
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High refill-adherence to adalimumab is associated with low disease activity in patients with inflammatory bowel disease
PurposeAdalimumab has evolved to one of the more affordable first-line biologics for the treatment of inflammatory bowel disease (IBD), since its...
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Effect Modification by Indication to the Risks of Major Thromboembolic Adverse Events in Patients Receiving Intravitreal Anti-Vascular Endothelial Growth Factor Treatment: A Population-Based Retrospective Cohort Study
BackgroundThe association between intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment and the risk of major thromboembolic...
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Guillain-Barré syndrome as clinical presentation of a recently acquired hepatitis C
About 40% of the Guillain-Barré syndrome (GBS) cases are associated with prodromal infections; occasionally, it has been associated to chronic...
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Traffic-related air pollution and supplemental folic acid intake in relation to DNA methylation in granulosa cells
BackgroundHigher exposure to traffic-related air pollution (TRAP) is related to lower fertility, with specific adverse effects on the ovary. Folic...
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Tabelecleucel: First Approval
Tabelecleucel (Ebvallo TM ) is an allogeneic Epstein–Barr virus (EBV)-specific T-cell immunotherapy that targets and eliminates EBV positive (EBV + )...
