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Prognostic factors associated with early recurrence following liver resection for colorectal liver metastases: a systematic review and meta-analysis
BackgroundColorectal cancer (CRC) is the 3rd most common malignancy with the liver being the most common site of metastases. The recurrence rate of...
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Identification of lineage-specific epigenetic regulators FOXA1 and GRHL2 through chromatin accessibility profiling in breast cancer cell lines
Breast cancer is a heterogeneous disease, and breast cancer cell lines are invaluable for studying this heterogeneity. However, the epigenetic...
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Association of hormone receptors and human epidermal growth factor receptor-2/neu expressions with clinicopathologic factors of breast carcinoma: a cross-sectional study in a tertiary care hospital, Kabul, Afghanistan
BackgroundBreast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The...
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BIRC5 expression by race, age and clinical factors in breast cancer patients
PurposeSurvivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target....
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Relationship between ER expression by IHC or mRNA with Ki67 response to aromatase inhibition: a POETIC study
BackgroundIn clinical practice, oestrogen receptor (ER) analysis is almost entirely by immunohistochemistry (IHC). ASCO/CAP recommends cut-offs...
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Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
IntroductionEstrogen receptor (ER) positive patients compromise about 70% of breast cancers. Tamoxifen, an antagonist of ERα66 (the classic ER), is...
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Histologic tumor type as a determinant of survival in hormone receptor-positive, HER2-negative, pT1-3 invasive ductal and lobular breast cancer
PurposeThe aim of the study was to compare the difference in survival between invasive ductal (IDC) and lobular carcinoma (ILC).
Methods ...
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Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association
BackgroundNon-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent...
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Identification of a novel ER-NFĸB-driven stem-like cell population associated with relapse of ER+ breast tumors
BackgroundUp to 40% of patients with estrogen receptor-positive (ER+) breast cancer experience relapse. This can be attributed to breast cancer stem...
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Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level
BackgroundIncreasing data indicate that HER2-positive (HER2 + ) breast cancer (BC) subtypes exhibit differential responses to targeted anti-HER2...
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New evidence: Metformin unsuitable as routine adjuvant for breast cancer: a drug-target mendelian randomization analysis
PurposeThe potential efficacy of metformin in breast cancer (BC) has been hotly discussed but never conclusive. This genetics-based study aimed to...
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The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients
IntroductionMatrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an...
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Relationship between tumor microbiota transcriptional activity and gene expression in breast cancer
BackgroundA few studies have reported the distribution of the microbiota in breast cancer tissues, but few reports have compared the microbiota in...
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Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
BackgroundThe relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between...
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The prognostic value of MEK pathway–associated estrogen receptor signaling activity for female cancers
BackgroundOther than for breast cancer, endocrine therapy has not been highly effective for gynecologic cancers. Endocrine therapy resistance in...
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An updated PREDICT breast cancer prognostic model including the benefits and harms of radiotherapy
PREDICT Breast ( www.breast .predict.nhs.uk ) is a prognostication tool for early invasive breast cancer. The current version was based on cases...
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Proficiency testing of diagnosis in histopathology and immunohistochemistry of breast pathology in China: results from a pilot work of National Single Disease Quality Control Program for breast cancer
AimPathologists are currently supposed to be aware of both domestic and international guidelines for breast cancer diagnosis, but it is unclear how...
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Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer
BackgroundIn breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics...
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Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers
BackgroundLatin American and Hispanic women are less likely to develop breast cancer (BC) than women of European descent. Observational studies have...
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Meta-analysis of integrated ChIP-seq and transcriptome data revealed genomic regions affected by estrogen receptor alpha in breast cancer
BackgroundThe largest group of patients with breast cancer are estrogen receptor-positive (ER + ) type. The estrogen receptor acts as a transcription...
