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Monooxygenase System and NO Metabolism in Liver Microsomes of Rats with Toxic Hepatitis and the Effect of Sesquiterpene Lactones
We analyzed changes in activities of enzymes of phases I and II of xenobiotic biotransformation and parameters of NO metabolism in liver microsomes...
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a...
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Fluid Biomarkers in Sports-Related Mild Traumatic Brain Injuries: Current Status and Novel Trends
Mild traumatic brain injury (mTBI) or concussion is the most common type of head injury reported worldwide, with millions of injuries occurring...
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Treatment with protocatechuic acid attenuates cisplatin-induced toxicity in the brain and liver of male Wistar rats
This study investigated the ameliorative effect of protocatechuic acid (PCA) in oxidative stress induced by cisplatin (CPL) in the brain and liver of...
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Achillea millefolium L., Common Yarrow
Yarrow (Achillea millefolium L.) is a common Asteraceae plant recognized in folk medicine throughout the globe, from Europe to Asia. The physical...
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High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability
Adaptive stress response pathways play a key role in the switch between adaptation and adversity, and are important in drug-induced liver injury....
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Elecampane rhizome extract alleviates methotrexate-induced hepatotoxicity and nephrotoxicity in male rats
Methotrexate (MTX) is a chemotherapy drug used to treat cancer and inflammatory diseases; however, its clinical applicability is limited due to its...
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Diarylheptanoids/sorafenib as a potential anticancer combination against hepatocellular carcinoma: the p53/MMP9 axis of action
Hepatocellular carcinoma (HCC) is a serious and potentially fatal form of cancer associated with liver damage. New anticancer drugs are increasingly...
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Recommended Resources for Biomarkers in Disease: Trauma, Injury, and Critical Care
It is extremely challenging to assess some victims of trauma, injury, or critical care. An accurate history may be difficult to obtain, and imaging...
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Circulating microRNAs as promising testicular translatable safety biomarkers: current state and future perspectives
Drug-induced testicular injury (DITI) is one of the often-observed and challenging safety issues seen during drug development. Semen analysis and...
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The Pathologist’s Approach to Reviewing Liver Histology
The pathological diagnosis of hepatobiliary diseases, particularly inflammatory diseases, is based on clinicopathological features. It is relatively...
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Comprehensive in vivo and in silico approaches to explore the hepatoprotective activity of poncirin against paracetamol toxicity
In the present study, poncirin was evaluated against paracetamol-induced liver injury using in vivo and computational approaches. Paracetamol was...
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RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study
BackgroundPregabalin (PGB) was approved as new anti-epileptic drugs with little information about its teratogenic effect.
Aim of the work ...
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Mechanisms of Drug-Induced Cholestasis
Cholestasis can be defined as any situation of impaired bile secretion with concomitant accumulation of bile acids in the liver or in the systemic...
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Alcohol-Associated Liver Disease
This chapter focuses on the immune-mediated aspects of the pathogenesis of alcohol-associated liver disease (ALD). Alcohol not only directly injuries...
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Potential nephroprotective effects of resveratrol in drug induced nephrotoxicity: a narrative review of safety and efficacy data
Drug induced nephrotoxicity commonly occurs in hospitalized patients and sometimes may complicate treatment outcome, especially in critically ill...
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Drug-induced hepatotoxicity among TB/HIV co-infected patients in a referral hospital, Ethiopia
ObjectivesAnti-tuberculosis drug-induced hepatotoxicity is a common serious adverse drug reaction. This study intended to determine the prevalence...
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Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury
Traumatic brain injury (TBI) triggers wide-ranging pathology that impacts multiple biochemical and physiological systems, both inside and outside the...
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Effectiveness and safety of Korean medicine for pain management after musculoskeletal surgery: a retrospective study
To assess the effectiveness and safety of Korean medicine in managing postoperative pain. Retrospective, observational study. Medical records of 233...
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Metabolite-Associated Disease Conditions
As a result of an imbalance between activation and detoxification metabolisms, reactive chemical intermediates and oxidative stress occur, leading to...