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The Par-4 Tumor Suppressor Protein in TCL1-Induced Leukemogenesis
Prostate apoptosis response 4 (Par-4) is a pleiotropic tumor suppressor protein that is downregulated in numerous solid tumors to evade its...
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Combination of RSK inhibitor LJH-685 and FLT3 inhibitor FF-10101 promoted apoptosis and proliferation inhibition of AML cell lines
PurposeFLT3 mutations occurred in approximately one third of patients with acute myeloid leukemia (AML). FLT3-ITD mutations caused the constitutive...
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Effective Murine Model Induction for Niche Study in Immune Cells Against Leukemia
Murine models have become powerful tools in leukemia research for investigating interactions between blast cells niche factors. In the tumor...
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Development and Evaluation of Stable Long Circulating Decitabine-loaded Copolymeric Nanoparticles: Harnessing QbD Approach and Lyophilization Technique
PurposeDecitabine is an inhibitor of DNA methyltransferase used to treat various types of leukemias. However, it is highly unstable in nature thereby...
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Pathological and therapeutic aspects of matrix metalloproteinases: implications in childhood leukemia
Matrix metalloproteinases (MMPs) play a major role in extracellular matrix remodeling and are involved in tumor cell invasion. Cancers such as...
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Macrolides for Cancer
Macrolides exert their antitumor effects through various mechanisms. Clarithromycin markedly reduced the incidence of mucosa-associated lymphoid...
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Types of Cancers, Epidemiology, and Molecular Insights
This chapter takes the readers through a comprehensive journey through the multifaceted landscape of cancer with insights into the fundamental...
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Molecular Characterization of Human Leukemia 60 (HL-60) Cells as a Model of Acute Myelogenous Leukemia Post Cryopreservation
The use of human leukemic (HL)-60 cells is important for studies of acute myeloid leukemia (AML) and as a model system for investigating how specific...
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Expanding anti-CD38 immunotherapy for lymphoid malignancies
BackgroundLymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer...
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Fisetin reduces the resistance of MOLT-4 and K562 cells to TRAIL-induced apoptosis through upregulation of TRAIL receptors
TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that is capable of apoptosis induction selectively in tumor cells....
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Haploidentical transplants deliver equal outcomes to matched sibling transplants: a propensity score-matched analysis
The success of allogeneic hematopoietic stem cell transplant for hematological malignancies is heavily dependent on the availability of suitable...
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Types of Cancers, Epidemiology, and Molecular Insights
This chapter takes the readers through a comprehensive journey through the multifaceted landscape of cancer with insights into the fundamental...
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Genetics of Cancer: Past, Present, and Future
Cancer is a disease of aberrant cells which evade the cell cycle checkpoints for proliferation and resists apoptotic signals. A cancer cell is...
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Advanced Therapeutic Approaches in Cancer Therapy
Recent advancements in cancer research have led to improved methods for early detection, prognostic monitoring, and innovative therapeutic...
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Advanced Therapeutic Approaches in Cancer Therapy
Recent advancements in cancer research have led to improved methods for early detection, prognostic monitoring, and innovative therapeutic...
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Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance
Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia...
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Molecular Biomarkers of Cancer and Their Diagnostic Applications
Cancer, characterized by abnormal cell growth, remains a significant global health concern. The intricate interplay of genetic, epigenetic, and...
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Genetic Modulation of Anticancer Drugs Affecting Pharmacokinetic for Safety and Efficacy
Cancer is a serious health issue which is caused by genetic alteration that leads to tremendous increases in cell growth in uncontrolled manner. The...
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Pharmacogenomics and Cancer Treatment
Somatic and germline genetic variations are two types of interindividual variations affecting drug response in cancer treatment. Pharmacogenomics...