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The emerging role of mass spectrometry-based proteomics in drug discovery
Proteins are the main targets of most drugs; however, system-wide methods to monitor protein activity and function are still underused in drug...
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Transcriptome Sequencing and Mass Spectrometry Reveal Genes Involved in the Non-mendelian Inheritance-Mediated Feather Growth Rate in Chicken
The feather growth rate in chickens included early and late feathering. We attempted to characterize the genes and pathways associated with the...
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Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
BackgroundThe cerebrospinal fluid (CSF) proteome could offer important insights into central nervous system (CNS) malignancies. To advance proteomic...
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Compound Identification Strategies in Mass Spectrometry-Based Metabolomics and Pharmacometabolomics
The metabolome is composed of a vast array of molecules, including endogenous metabolites and lipids, diet- and microbiome-derived substances,...
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Multicompartmental High-Throughput Metabolomics Based on Mass Spectrometry
Multicompartmental metabolomics is a powerful strategy for studying organism metabolic homeostasis in a holistic manner. To this end, mass...
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Determination of Cytosine Modifications in DNA by Chemical Labeling-Mass Spectrometry Analysis
In active DNA demethylation, DNA cytosine methylation (5-methylcytosine, 5-mC) can be converted to 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine...
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Mass Spectrometry-Based Quantification of β-d-Glucosyl-5-Hydroxymethyluracil in Genomic DNA
Base J, or β-d-glucosyl-5-hydroxymethyluracil, is the first hypermodified nucleobase that has been discovered in eukaryotes. It has been found in the...
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Single-Cell Mass Spectrometry of Metabolites and Proteins for Systems and Functional Biology
Molecular composition is intricately intertwined with cellular function, and elucidation of this relationship is essential for understanding life...
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Toxicokinetics of plasmatic VX in a swine model: comparison of a simple enzymatic titration method with a mass spectrometry method
Recent events have shown that organophosphorus nerve agents (OPNAs) are a serious threat. Cholinesterase inhibition by OPNAs results in acetylcholine...
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Multiresidue Pesticide Analysis in Okra (Ladyfinger) Using Gas Chromatography Tandem Mass Spectrometry (GC-MS/MS)
The presence of pesticide residues in food and vegetables is a growing concern for consumers. In order to monitor these residues reliably, a...
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Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to...
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Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients
BackgroundAs leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern....
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Falsified and problematic methandienone products available online: active pharmaceutical ingredient identification by portable Raman spectrometers and quantification by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry
This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic...
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Effects of Selection of the Learning Set Formation Strategy and Filtration Method on the Effectiveness of a BCI Based on Near Infrared Spectrometry
We propose an algorithm for the operation of a brain–computer interface based on recording hemodynamic activity using near-infrared spectrometry...
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Liquid Chromatography-Mass Spectrometry Analysis of Peripheral Blood Mononuclear Cells from SARS-CoV-2 Infected Patients
COVID-19 disease is caused by infection with the SARS-CoV-2 virus and is associated with a cytokine storm effect in some patients. This can lead to...
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Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics
This chapter presents the fundamentals, instrumentation, methodology, and applications of capillary electrophoresis-mass spectrometry (CE-MS) for...
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Recent Advances in Understanding of Alzheimer’s Disease Progression Through Mass Spectrometry-Based Metabolomics
Alzheimer’s disease (AD) is the leading cause of dementia in the aging population, but despite extensive research, there is no consensus on the...
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Isolation and Identification of Dengue Virus Interactome with Human Plasma Proteins by Affinity Purification-Mass Spectrometry
Viral proteins evolve to benefit the interaction with host proteins during the infection and replication processes. A comprehensive understanding of...
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Capillary Electrophoresis–Mass Spectrometry of Hydrophilic Metabolomics
Metabolomics is defined as the comprehensive identification and quantification of small molecules that provide a holistic view of cellular...