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Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising avenue for addressing lung...
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Connexins may play a critical role in cigarette smoke-induced pulmonary hypertension
Pulmonary hypertension (PH) is a chronic progressive disease characterized by pulmonary vasoconstriction and remodeling. It causes a gradual increase...
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Influence of Polymer Stiffness and Geometric Design on Fluid Mechanics in Tissue-Engineered Pulmonary Valve Scaffolds
There is still much unknown about the fluid mechanical response to cardiac valve scaffolds, even as their implementation in the clinic is on the...
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Molecular Pathways and Animal Models of Tetralogy of Fallot and Double Outlet Right Ventricle
Tetralogy of Fallot and double-outlet right ventricle are outflow tract (OFT) alignment defects situated on a continuous disease spectrum. A myriad...
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Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study
PurposeThe geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and...
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New tricks for old drugs- praziquantel ameliorates bleomycin-induced pulmonary fibrosis in mice
BackgroundPulmonary fibrosis is a chronic progressive disease with complex pathogenesis, short median survival time, and high mortality. There are...
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Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure
PurposrThis study created 3D CFD models of the Norwood procedure for hypoplastic left heart syndrome (HLHS) using standard angiography and...
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AMPKα2 deficiency exacerbates hypoxia-induced pulmonary hypertension by promoting pulmonary arterial smooth muscle cell proliferation
Increased evidence indicates that adenosine monophosphate-activated protein kinase (AMPK) plays a vital role in vascular homeostasis, especially...
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Modeling of Acute Pulmonary Arterial Hypertension in Pigs Using a Stable Thromboxane A2 Analogue (U46619): Dose Adjustment and Assessment of Hemodynamic Reactions
U46619, a synthetic analogue of thromboxane A2 was used for modeling acute stable and reversible pulmonary arterial hypertension. Administration of...
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SARS-CoV-2 and pathological matrix remodeling mediators
BackgroundRecognizing only sharp elevation in a short period of time, the COVID-19 SARS-CoV-2 propagation is more and more marked in the whole world....
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Applications of Nanotechnology in Pulmonary Disease Diagnosis
Nanotechnology is one of the highest priority research areas in medicine and a potentially useful tool for the diagnosis and treatment of pulmonary...
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Mechanosensing and Mechanotransduction in Pulmonary Hypertension
Pulmonary hypertension (PH) is a devastating disease with a poor outcome. Progressive remodeling of the pulmonary microvasculature leads to an...
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Molecular hydrogen is a promising therapeutic agent for pulmonary disease
Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes...
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Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
BackgroundPulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to...
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Therapeutic Advances in the Management of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease with multiple etiologies. If remains untreated, it leads to high rate of morbidity and...
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The role of vasculature and angiogenesis in respiratory diseases
In European countries, nearly 10% of all hospital admissions are related to respiratory diseases, mainly chronic life-threatening diseases such as...
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An intronic variant in TBX4 in a single family with variable and severe pulmonary manifestations
A male infant presented at term with neonatal respiratory failure and pulmonary hypertension. His respiratory symptoms improved initially, but he...
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MicroRNA miR-627-5p restrains pulmonary artery smooth muscle cell dysfunction by targeting MAP 2 K4 and PI3K/AKT signaling
BackgroundChronic obstructive pulmonary disease (COPD) is characterized by pulmonary vascular remodeling, which can be caused by abnormal...
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The Biomechanics of Venous Remodeling
The remodeling of veins is associated with an alteration of both the architecture as well as the functional properties of the vein wall. On the...
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Inflow Tract Development
The development of the inflow tract is undoubtedly one of the most complex remodeling events in the formation of the four-chambered heart. It...