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Anodal HD-tDCS on the dominant anterior temporal lobe and dorsolateral prefrontal cortex: clinical results in patients with mild cognitive impairment
ObjectivesMild cognitive impairment (MCI) is a neurocognitive disorder in which the cognitive and mental abilities of humans are declined....
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27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice
BackgroundCognitive impairment is associated with dysregulated immune responses. Emerging evidence indicates that Th17 cells and their characteristic...
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Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis
The microstructural characteristics of white and gray matter in mild cognitive impairment (MCI) and the early-stage of Alzheimer’s disease (AD)...
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Hippocampus-centred grey matter covariance networks predict the development and reversion of mild cognitive impairment
BackgroundMild cognitive impairment (MCI) has been thought of as the transitional stage between normal ageing and Alzheimer’s disease, involving...
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Beta to theta power ratio in EEG periodic components as a potential biomarker in mild cognitive impairment and Alzheimer’s dementia
BackgroundAlzheimer’s dementia (AD) is associated with electroencephalography (EEG) abnormalities including in the power ratio of beta to theta...
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Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer’s disease using EEG technology
BackgroundElectroencephalogram (EEG) has emerged as a non-invasive tool to detect the aberrant neuronal activity related to different stages of...
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Behavioral Interventions in Mild Cognitive Impairment (MCI): Lessons from a Multicomponent Program
Comparative effectiveness of behavioral interventions to mitigate the impacts of degeneration-based cognitive decline is not well understood. To...
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Atrophy asymmetry in hippocampal subfields in patients with Alzheimer’s disease and mild cognitive impairment
Volumetric analysis of hippocampal subfields and their asymmetry assessment recently has been useful biomarkers in neuroscience. In this study,...
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The Early Stage of Abnormal Aging: Cognitive Impairment
Cognitive impairment has become an important aspect affecting the health and quality of life of middle-aged and elderly people, which is defined as...
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Evolution of brain network dynamics in early Parkinson’s disease with mild cognitive impairment
How mild cognitive impairment (MCI) is instantiated in dynamically interacting and spatially distributed functional brain networks remains an...
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Parkinson’s disease CA2-CA3 hippocampal atrophy is accompanied by increased cholinergic innervation in patients with normal cognition but not in patients with mild cognitive impairment
Although brain cholinergic denervation has been largely associated with cognitive decline in patients with Parkinson’s disease (PD), new evidence...
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Disruption of early visual processing in amyloid-positive healthy individuals and mild cognitive impairment
BackgroundAmyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving...
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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease: A Data-Driven Meta-Analysis with N = 3,118
The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease (AD). We...
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Effects of computerized cognitive training on structure‒function coupling and topology of multiple brain networks in people with mild cognitive impairment: a randomized controlled trial
BackgroundPeople with mild cognitive impairment (MCI) experience a loss of cognitive functions, whose mechanism is characterized by aberrant...
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Hippocampus-based static functional connectivity map** within white matter in mild cognitive impairment
Mild cognitive impairment (MCI) is clinically characterized by memory loss and cognitive impairment closely associated with the hippocampal atrophy....
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Detection of mild cognitive impairment in Parkinson’s disease using gradient boosting decision tree models based on multilevel DTI indices
BackgroundCognitive dysfunction is the most common non-motor symptom in Parkinson’s disease (PD), and timely detection of a slight cognitive decline...
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Medication management and treatment adherence in Parkinson's disease patients with mild cognitive impairment
IntroductionThe key feature that distinguishes mild cognitive impairment (MCI) from dementia is the absence of significant functional decline because...
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Volume changes of hippocampal and amygdala subfields in patients with mild cognitive impairment and Alzheimer’s disease
BackgroundAutomated segmentation of hippocampal and amygdala subfields could improve classification accuracy of Mild Cognitive Impairments (MCI) and...
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Semantic fluency deficits and associated brain activity in Parkinson’s disease with mild cognitive impairment
People living with Parkinson’s disease (PD) with poor verbal fluency have an increased risk of develo** dementia. This study examines the neural...
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Plasma adiponectin levels predict cognitive decline and cortical thinning in mild cognitive impairment with beta-amyloid pathology
BackgroundBlood adiponectin and leptin are adipokines that emerged as potential biomarkers for predicting Alzheimer’s disease (AD) owing to their...
