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In Vivo Imaging of Tfh Cells
Germinal centers (GCs) are microanatomical structures in secondary lymphoid organs where B cells undergo affinity maturation for antigen during the...
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In vivo imaging of inflammatory response in cancer research
Inflammation can contribute to the development and progression of cancer. The inflammatory responses in the tumor microenvironment are shaped by...
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Using Intravital Microscopy to Study the Role of MIF in Leukocyte Trafficking In Vivo
In vivo visualization of the microvasculature of the mouse cremaster muscle has been fruitful in the evaluation of the role of macrophage migration...
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ROS-activated CXCR2+ neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosis
Neutrophils are the earliest master inflammatory regulator cells recruited to target tissues after direct infection or injury. Although inflammatory...
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Evaluation of Blood-CSF Barrier Transport by Quantitative Real Time Fluorescence Microscopy
PurposeTransporters at the blood-cerebrospinal fluid (CSF) barrier (BCSFB) play active roles in removing drugs and toxins from the CSF. The goal of...
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On Optimizing Miniscope Data Analysis with Simulated Data: A Study of Parameter Optimization in the Minian Analysis Pipeline
In vivo calcium imaging is widely used in neuroscience to assess the activity of neuronal ensembles. The advent of the single-photon miniature...
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Impact of microparticles released during murine systemic inflammation on macrophage activity and reactive nitrogen species regulation
Microparticles (MPs) packaged with numerous bioactive molecules are essential vehicles in cellular communication in various pathological conditions,...
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Recording Leukocyte Rolling and Adhesion on Meningeal Vessels by Intravital Microscopy
Leukocyte infiltration in the central nervous system (CNS) has been implicated in several neuroinflammatory diseases, being an important step in the...
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Two-Photon Phosphorescence Lifetime Microscopy
Two-photon Phosphorescence Lifetime Microscopy (2PLM) is an emerging nonlinear optical technique that has great potential to improve our...
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Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins
Colchicine is an anti-inflammatory drug with a narrow therapeutic index. Its binding to tubulin prevents microtubule polymerization; however, little...
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Cancer cell extravasation requires iplectin-mediated delivery of MT1-MMP at invadopodia
BackgroundInvadopodia facilitate cancer cell extravasation, but the molecular mechanism whereby invadopodia-specific proteases such as MT1-MMP are...
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Coalescent angiogenesis—evidence for a novel concept of vascular network maturation
Angiogenesis describes the formation of new blood vessels from pre-existing vascular structures. While the most studied mode of angiogenesis is...
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Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior
BackgroundBehavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause...
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A transmissible γδ intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IELs) serve as a first line of defense against luminal microbes. Although the...
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Inflammation triggers ILC3 patrolling of the intestinal barrier
An orchestrated cellular network, including adaptive lymphocytes and group 3 innate lymphoid cells (ILC3s), maintains intestinal barrier integrity...
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High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue
Histological examinations typically require the excision of tissue, followed by its fixation, slicing, staining, mounting and imaging, with...
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Micro-endoscopy for Live Small Animal Fluorescent Imaging
Intravital microscopy has emerged as a powerful technique for the fluorescent visualization of cellular- and subcellular-level biological processes...
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Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis
Cancer mortality rates are primarily a result of cancer metastasis. Recent advances in microscopy technology allow for the imaging of circulating...
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Neutrophil–macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome
Cytokine storm syndrome (CSS) is a life-threatening systemic inflammatory syndrome involving innate immune hyperactivity triggered by various...
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TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice
BackgroundMetabolic syndrome (MS) is defined as a low-grade proinflammatory state in which abnormal metabolic and cardiovascular factors increase the...
