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Comparisons of 25 cerebrospinal fluid cytokines in a case–control study of 106 patients with recent-onset depression and 106 individually matched healthy subjects
BackgroundNeuroinflammation has been suggested as a contributor to the pathophysiology of depression; however, large case–control studies...
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Low-dose interleukin-2 can improve salivary secretion but not lymphocyte infiltration of salivary glands in a murine model of Sjögren’s syndrome
Introduction/aimEffects of low-dose interleukin-2 (IL-2) on the exocrine glandular glands of Sjögren’s syndrome are unknown. The aim of this study...
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Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases
Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin deacetylases Cda1 and Cda2 protect mice against experimental...
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Unilateral acute lung injury in pig: a promising animal model
BackgroundAcute lung injury (ALI) occurs in 23% unilateral. Models of unilateral ALI were developed and used previously without clearly demonstrating...
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IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40
The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin (IL)-23. This...
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Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta
This study evaluated the composition and the antinociceptive and anti-inflammatory activity of the crude extracts and two isolated compounds,...
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Clinical Trials of IL-12/IL-23 Inhibitors in Inflammatory Bowel Disease
The inflammatory bowel diseases (IBDs) are chronic immune-mediated inflammatory disorders, including ulcerative colitis (UC) and Crohn’s disease...
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Intestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation
BackgroundVariations exist in the response of patients with Crohn’s disease (CD) to ustekinumab (UST) treatment, but the underlying cause remains...
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Cornuside alleviates experimental autoimmune encephalomyelitis by inhibiting Th17 cell infiltration into the central nervous system
The present study was conducted to clarify the therapeutic effect of cornuside on experimental autoimmune encephalomyelitis (EAE) and its influence...
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Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway
Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been...
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Comparing Flow Cytometry and ELISpot for Detection of IL-10, IL-6, and TNF Alpha on Human PBMCs
ELISpot and flow cytometry are two methods often utilized side-by-side for detecting secreted and intracellular cytokines, respectively. Each...
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Novel Targeted Biological Agents for the Treatment of Atopic Dermatitis
Atopic dermatitis (AD) is a common inflammatory dermatologic disease clinically characterized by intense itch, recurrent eczematous lesions, and a...
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Dissecting Interleukin-6 Classic and Trans-signaling in Inflammation and Cancer
Interleukin-6 (IL-6) is a cytokine synthesized by many cells in the human body. IL-6 binds to a membrane-bound receptor (IL-6R), which is only...
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Cytokines inhibitory mechanism of Prunus domestica L. (Plum) peptides as potential immunomodulators against systemic lupus erythematosus: an in-silico screening
Natural bioactive peptides exhibit various chemical and structural properties to enhance the immune response against multiple inflammatory and...
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High-Plex ELISPOT: FOLISPOT Based on Fluorescence Detection and DNA Complementary Pairing
Enzyme-linked immunospot (ELISPOT) is one of the most important methods to measure the number of specific cells by detecting protein secretion at a...
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Lumit: A Homogeneous Bioluminescent Immunoassay for Detecting Diverse Analytes and Intracellular Protein Targets
Traditional immunoassays to detect secreted or intracellular proteins can be tedious, require multiple washing steps, and are not easily adaptable to...
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Melanoma Immunotherapy
Melanoma is considered a highly immunogenic tumor due to its high level of somatic mutations and frequent expression of type I interferons. As such,...
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Interferons and Interleukins
In this chapter, the complex role of interferons and interleukins in our defense system to defend against, contain, or eliminate toxic or invasive...
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Lessons on SpA pathogenesis from animal models
Understanding the complex mechanisms underlying a disorder such as spondyloarthritis (SpA) may benefit from studying animal models. Several suitable...
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Clinical Trials and Outcomes in Anti-inflammatory Therapies
Inflammatory diseases represent a diverse group of disorders stemming from an overactive immune response, affecting various organs and tissues and...