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Molecular Mechanisms of Metal-Induced Carcinogenesis
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused...
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Characterization of Chromosomal and Repetitive Elements in the Genome of “Rana nigrovittata” (Anura, Ranidae): Revealed by Classical and Molecular Techniques
AbstractKaryotype study and microsatellites pattern in the genome of Rana nigrovittata were studied, with the aim to provide a standard karyotype,...
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Biotechnology in Medicine: Advances-I
The recent advances in biologic medicine have paved a way to successful treatment of patients with serious diseases such as cancer, neurological...
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Distinct genome-wide DNA methylation and gene expression signatures in classical monocytes from African American patients with systemic sclerosis
BackgroundSystemic sclerosis (SSc) is a multisystem autoimmune disorder that has an unclear etiology and disproportionately affects women and African...
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Sex chromosome evolution in frogs—helpful insights from chromosome painting in the genus Engystomops
The differentiation of sex chromosomes is thought to be interrupted by relatively frequent sex chromosome turnover and/or occasional recombination...
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Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
BackgroundSex hormones and sex chromosomes play a vital role in cardiovascular disease. Testosterone plays a crucial role in men’s health. Lower...
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Pancreatic cancer epigenetics: adaptive metabolism reprograms starving primary tumors for widespread metastatic outgrowth
Pancreatic cancer is a paradigm for adaptation to extreme stress. That is because genetic drivers are selected during tissue injury with epigenetic...
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Epigenetics of Cardiomyopathy: Histone Modifications and DNA Methylation
AbstractCardiomyopathies are an actively investigated clinically and genetically heterogeneous group of myocardial pathologies. At present, it is...
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Acrylamide, Applied During Pregnancy and Postpartum Period in Offspring Rats, Significantly Disrupted Myelination by Decreasing the Levels of Myelin-Related Proteins: MBP, MAG, and MOG
Acrylamide (ACR) is a colorless, odorless, and water-soluble solid molecule. In addition to being an important industrial material, ACR is found in...
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Abnormal Chromatin Folding in the Molecular Pathogenesis of Epilepsy and Autism Spectrum Disorder: a Meta-synthesis with Systematic Searching
How DNA is folded and packaged in nucleosomes is an essential regulator of gene expression. Abnormal patterns of chromatin folding are implicated in...
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Histone Modifications
In this chapter, we will present posttranslational modifications as a general mechanism for instructing proteins about their function. Moreover, they...
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Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation
BackgroundNeutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation and tissue...
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Intragenomic rDNA variation - the product of concerted evolution, mutation, or something in between?
The classical model of concerted evolution states that hundreds to thousands of ribosomal DNA (rDNA) units undergo homogenization, making the...
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Regulation of Uni-Strand and Dual-Strand piRNA Clusters in Germ and Somatic Tissues in Drosophila melanogaster under Control of rhino
AbstractDrosophila melanogaster is a common genetic object for research of RNA interference pathways and regulation of mobile elements. At present,...
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MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer
BackgroundInhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer...
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Small Supernumerary Ring Chromosomes
Small supernumerary ring chromosomes (sSRCs) are a specific subgroup of ring chromosomes (RCs) normally present in addition to an otherwise normal...
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The potential protective and therapeutic effects of cannabidiol oil on experimental Leukemia induced by DMBA in male rats
Background7,12-Dimethylbenzanthracene (DMBA) is a member of the polycyclic aromatic hydrocarbon family. It is a member of the polycyclic aromatic...
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Epigenetic Mechanisms: DNA Methylation and Histone Protein Modification
Epigenetic Regulation Allows Control of Differential Gene Expression from the Same Genome. Every somatic cell in a given organism contains the same...
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Viral remodeling of the 4D nucleome
The dynamic spatial organization of genomes across time, referred to as the four-dimensional nucleome (4DN), is a key component of gene regulation...
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Resha** the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers, especially those...
