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Detection of Paraptosis After Photodynamic Therapy
Photodynamic therapy (PDT)Photodynamic therapy (PDT) is a procedure for the selective photosensitization of neoplastic tissues. Subsequent...
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Clinical impact of spacer placement surgery with expanded polytetrafluoroethylene sheet for particle therapy
BackgroundSpacer placement surgery is useful in particle therapy (PT) for patients with abdominopelvic malignant tumors located adjacent to the...
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Adoptive T-Cell Therapy for the Treatment of Lung Cancer
Lung cancer is an imminent health threat and the predominant cause of cancer-related fatalities worldwide. Significant advancements in identifying...
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Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with anti-PDL1 therapy effectively inhibits triple-negative breast cancer growth and metastasis
BackgroundAdoptive cell transfer cancer immunotherapy holds promise for treating disseminated disease, yet generating sufficient numbers of...
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Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction
Despite the presence of clinical guidelines recommending that β-blocker treatment be initiated early after reperfused myocardial infarction (RMI),...
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Frontline treatment patterns and attrition rates by subsequent lines of therapy in patients with newly diagnosed multiple myeloma
BackgroundFor patients with multiple myeloma (MM), each additional line of therapy (LOT) is associated with lower response rates, shorter treatment...
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Challenges of Treatment Methodologies and the Future of Gene Therapy and Stem Cell Therapy to Treat Retinitis Pigmentosa
Retinitis pigmentosa (RP) is a heterogeneous group of hereditary retinal degenerations for which there is currently no cure. Studies investigating...
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Gastrointestinal Side Effects of Anticancer Therapy
Cancer treatments have been key to improve survivorship of patients affected by this dreadful disease. Among these, cytotoxic chemotherapy and, in...
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Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial
BackgroundRelapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line...
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Photobiomodulation therapy moderates cancer cachexia-associated muscle wasting through activating PI3K/AKT/FoxO3a pathway
Cancer cachexia-associated muscle wasting as a multifactorial wasting syndrome, is an important factor affecting the long-term survival rate of tumor...
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Comprehensive multiplexed immune profiling of the ductal carcinoma in situ immune microenvironment regarding subsequent ipsilateral invasive breast cancer risk
BackgroundDuctal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will...
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A multinational survey of potential participant perspectives on ocular gene therapy
Amidst rapid advancements in ocular gene therapy, understanding patient perspectives is crucial for sha** future treatment choices and research...
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Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution
The biological complexity of cancer represents a tremendous clinical challenge, resulting in the frequent failure of current treatment protocols. In...
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Chronobiology and Nanotechnology for Personalized Cancer Therapy
As a consequence of Earth’s rotation in its axis, most organisms in this planet are subjected to a 24-hour variation in light and temperature. A...
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Diabetes Mellitus and iPSC-Based Therapy
At present, the number of diabetes mellitus (DM) patients has exceeded 537 million worldwide, and this number continues to increase. Type 1 diabetes...
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Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases
The ultimate and most complex form of treating human diseases is embodied by gene therapy. For an effective gene therapeutic product we need to hack...
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A new era of macrophage-based cell therapy
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When...
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Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution
Cancer development is an evolutionary process. A key selection pressure is exerted by therapy, one of the few players in cancer evolution that can be...
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Applications of Photodynamic Therapy for the Eradication of ESKAPE Pathogens
Antimicrobial photodynamic therapy (aPDT) is one of the efficient and alternate therapeutic strategies to combat planktonic and biofilm cells of...