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Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent
The effects of contezolid (MRX-I, an oxazolidinone antibacterial agent) on cardiac repolarization were evaluated retrospectively using a population...
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Antidotal Sodium Bicarbonate Therapy: Delayed QTc Prolongation and Cardiovascular Events
BackgroundSodium bicarbonate therapy (SBT) is currently indicated for the management of a variety of acute drug poisonings. However, SBT effects on...
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When Manual Analysis of 12-Lead ECG Holter Plays a Critical Role in Discovering Unknown Patterns of Increased Arrhythmogenic Risk: A Case Report of a Patient Treated with Tamoxifen and Subsequent Pneumonia in COVID-19
Several medicines, including cancer therapies, are known to alter the electrophysiological function of ventricular myocytes resulting in abnormal...
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A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2
Mutations in hERG (human ether-à-go-go-related gene) potassium channel are closely associated with long QT syndromes. By direct Sanger sequencing, we...
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Longitudinal study based on a safety registry for malaria patients treated with artenimol–piperaquine in six European countries
BackgroundEuropean travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of...
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The Neuro-cardiac Axis in Arrhythmogenesis: Role and Impact of Autonomic Modulation
The autonomic nervous system consisting of two limbs, the sympathetic and parasympathetic nervous system, plays a key role in the modulation of...
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Open-access database of literature derived drug-related Torsade de Pointes cases
Since an introduction of an ICH guidance in 2005, no new drugs were withdrawn from the market because of the causation of Torsade de Pointes (TdP)....
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Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase
PurposeTo analyze the cases of torsade de pointes (TdP) and related symptoms reported in association with chloroquine (CQ), hydroxychloroquine (HCQ),...
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A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity
PurposeAlthough doxorubicin chemotherapy is commonly applied for treating different malignant tumors, cardiotoxicity induced by this chemotherapeutic...
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CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy
BackgroundAnamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis....
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Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study
BackgroundPolypharmacy, defined as the concurrent use of over six drugs, is common in the treatment of heart failure (HF); however, unpredictable...
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Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
Calcium (Ca 2+ ) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper...
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CACNA1C-Related Channelopathies
The CACNA1C gene encodes the pore-forming subunit of the CaV1.2 L-type Ca2+ channel, a critical component of membrane physiology in multiple tissues,...
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Arrhythmias related to antipsychotics and antidepressants: an analysis of the summaries of product characteristics of original products approved in Germany
PurposeMost psychiatric drugs, such as antidepressants (AD) and antipsychotics (AP), may cause cardiac adverse events (CAE). We used summaries of...
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The effect of an anti-malarial herbal remedy, Maytenus senegalensis, on electrocardiograms of healthy Tanzanian volunteers
BackgroundThe emergence of resistance to artemisinin-based combination therapy necessitates the search for new, more potent antiplasmodial compounds,...
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Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review
RationaleManagement of anxiety, delirium, and agitation cannot be neglected in coronavirus disease (COVID-19). Antipsychotics are usually used for...
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Tocotrienols-enriched Self-nanoemulsifying Drug Delivery System Enhances the Antileukemic Activity of All-trans Retinoic Acid but not Electrocardiogram Alterations Evoked by Its Combination with Arsenic Trioxide
All- trans retinoic acid and arsenic trioxide are the leading choices for the treatment of acute promyelocytic leukemia. Notwithstanding the...
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Biophysical mechanisms of myocardium sodium channelopathies
Genetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated sodium channel Na v 1.5 are associated with various diseases,...
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How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology – model-based case study
The circadian rhythm of cardiac electrophysiology is dependent on many physiological and biochemical factors. Provided, that models describing the...
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Divergent Electrophysiological Effects of Loperamide and Naloxone in a Sensitive Whole-Heart Model
Several case reports suggest QT prolongation leading to ventricular arrhythmias with fatal outcome after intoxication with the μ-opioid receptor...
