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Risk factors for contralateral breast cancer in postmenopausal breast cancer survivors in the NIH-AARP Diet and Health Study
PurposeThe role of established breast cancer risk factors and clinical characteristics of the first breast cancer in the development of contralateral...
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Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case–control study of the Multiethnic Cohort Study
BackgroundLaboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC),...
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Reproductive characteristics, menopausal status, race and ethnicity, and risk of breast cancer subtypes defined by ER, PR and HER2 status: the Breast Cancer Etiology in Minorities study
BackgroundAssociations between reproductive factors and risk of breast cancer differ by subtype defined by joint estrogen receptor (ER), progesterone...
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CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis
Breast cancer is one of the most common types of malignancy diagnosed among females worldwide. Due to its heterogenous nature, the type of treatment...
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Extended adjuvant endocrine therapy in a longitudinal cohort of young breast cancer survivors
Extended adjuvant endocrine therapy (eET) improves outcomes in breast cancer survivors. Most studies however have been limited to postmenopausal...
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Personalized Medicine in Clinical Management of Breast Cancer: Where Do We Stand?
Breast cancer, the most common cancer occurring worldwide, is characterized by varied clinicopathological features. The current classification based...
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Measured body size and serum estrogen metabolism in postmenopausal women: the Ghana Breast Health Study
BackgroundSeveral anthropometric measures have been associated with hormone-related cancers, and it has been shown that estrogen metabolism in...
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Prolactin levels and breast cancer risk by tumor expression of prolactin-related markers
BackgroundHigher circulating prolactin has been associated with increased breast cancer risk. Prolactin binding to the prolactin receptor (PRLR) can...
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Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women
Breast cancer is the most common cancer among US Hispanics/Latinas; however, Hispanic/Latina women in the United States have historically shown a...
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Diagnostic-Prognostic Biomarkers and Their Clinical Implication in Breast Cancer
Breast cancer (BC) is a complex disease that continues to affect global cancer fatalities with its high incidence rate. Hence, BC requires...
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A prospective case–cohort analysis of plasma metabolites and breast cancer risk
BackgroundBreast cancer incidence rates have not declined despite an improvement in risk prediction and the identification of modifiable risk...
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Birthweight, childhood body size, and timing of puberty and risks of breast cancer by menopausal status and tumor receptor subtypes
BackgroundAssociations of birthweight, childhood body size and pubertal timing with breast cancer risks by menopausal status and tumor receptor...
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Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics
PurposeCancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms...
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Racial differences in anthropometric measures as risk factors for triple-negative breast cancer
PurposeThe incidence of triple-negative breast cancer (TNBC) is higher in Black women compared to White women which is not explained by racial...
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Dual effect of vitamin D3 on breast cancer-associated fibroblasts
BackgroundCancer-associated fibroblasts (CAFs) play an important role in the tumor microenvironment. Despite the well-known in vitro antitumoral...
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The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity...
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Recent progress of CDK4/6 inhibitors’ current practice in breast cancer
Dysregulated cellular proliferation represents a hallmark feature across all cancers. Aberrant activation of the cyclin-dependent kinase 4 and 6...
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The Microbiome: A New Frontier in Overcoming Drug Resistance in Breast Cancer
The gut microbiome comprises bacteria, fungi, viruses, archaea, and their genetic materials. The gut microbiome influences the physiological and...
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AMEERA-4: a randomized, preoperative window-of-opportunity study of amcenestrant versus letrozole in early breast cancer
BackgroundWindow-of-opportunity (WOO) studies provide insights into the clinical activity of new drugs in breast cancer.
MethodsAMEERA-4...
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Healthy lifestyles, systemic inflammation and breast cancer risk: a mediation analysis
BackgroundDespite the known association between healthy lifestyles and reduced risk of breast cancer, it remains unclear whether systemic...
