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Criticality in Alzheimer’s and healthy brains: insights from phase-ordering
Criticality, observed during second-order phase transitions, is an emergent phenomenon. The brain operates near criticality where complex systems...
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Potential biomarker for early detection of ADHD using phase-based brain connectivity and graph theory
This research investigates an efficient strategy for early detection and intervention of attention-deficit hyperactivity disorder (ADHD) in children....
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Motoneurone synchronization for intercostal and abdominal muscles: interneurone influences in two different species
The contribution of branched-axon monosynaptic inputs in the generation of short-term synchronization of motoneurones remains uncertain. Here,...
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Experimental Medicine Approaches in Early-Phase CNS Drug Development
Traditionally, Phase 1 clinical trials were largely conducted in healthy normal volunteers and focused on collection of safety, tolerability, and... -
Neural Oscillations and Multisensory Processing
Neural oscillations play a role in sensory processing by coordinating synchronized neuronal activity. Synchronization of gamma oscillations is... -
Reverse Inhibitory Connections via GABAB-Receptors Synchronize Interictal Discharges in the Cortex
Current experimental evidence shows that interictal discharges consist of a short spike and a slow wave, which is regarded as long-lasting...
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The ankle dorsiflexion kinetics demand to increase swing phase foot-ground clearance: implications for assistive device design and energy demands
BackgroundThe ankle is usually highly effective in modulating the swing foot’s trajectory to ensure safe ground clearance but there are few reports...
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Quantitative comparison of the mean–return-time phase and the stochastic asymptotic phase for noisy oscillators
Seminal work by A. Winfree and J. Guckenheimer showed that a deterministic phase variable can be defined either in terms of Poincaré sections or in...
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Circadian phase advances in children during cam** life according to the natural light-dark cycle
BackgroundIt is known that the circadian rhythm phase in adults can be advanced in a natural light-dark cycle without electrical lighting. However,...
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Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types
Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. However, whether...
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A distributed theta network of error generation and processing in aging
Based on previous concepts that a distributed theta network with a central “hub” in the medial frontal cortex is critically involved in movement...
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Within-group synchronization in the prefrontal cortex associates with intergroup conflict
Individuals immersed in groups sometimes lose their individuality, take risks they would normally avoid and approach outsiders with unprovoked...
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The impact of lesion side on bilateral upper limb coordination after stroke
BackgroundA stroke frequently results in impaired performance of activities of daily life. Many of these are highly dependent on effective...
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Phase-shifted tACS can modulate cortical alpha waves in human subjects
In the present study, we investigated traveling waves induced by transcranial alternating current stimulation in the alpha frequency band of healthy...
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Characteristics of corticomuscular coupling during wheelchair Tai Chi in patients with spinal cord injury
BackgroundWheelchair Tai Chi (WCTC) has been proved to have benefits for the brain and motor system of spinal cord injury (SCI) patients. However,...
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Artificial Neural Network-Based Activities Classification, Gait Phase Estimation, and Prediction
Gait patterns are critical to health monitoring, gait impairment assessment, and wearable device control. Unrhythmic gait pattern detection under...
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Comparison of event-related modulation index and traditional methods for evaluating phase-amplitude coupling using simulated brain signals
The investigation of brain oscillations and connectivity has become an important topic in the recent decade. There are several types of interactions...
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Assessing Neural Circuit Interactions and Dynamics with Phase-Amplitude Coupling
Complex biological systems exhibit periodicity at multiple frequencies, and these rhythms are rarely independent, exhibiting many forms of coupling...