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Synergisms of genome and metabolism stabilizing antitumor therapy (GMSAT) in human breast and colon cancer cell lines: a novel approach to screen for synergism
BackgroundDespite an improvement of prognosis in breast and colon cancer, the outcome of the metastatic disease is still severe. Microevolution of...
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A sco** review on tsetse fly blood meal sources and its assay methods since 1956 to 2022
BackgroundTsetse flies ( Glossina spp.) are the definitive biological vectors of African trypanosomes in humans and animals. Controlling this vector...
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MiR-128-3p Attenuates the Neurotoxicity in Rats Induced by Isoflurane Anesthesia
Isoflurane (ISO) has been widely used in clinical anesthesia, and exposure to ISO leads to cognitive dysfunction. Our paper aimed to investigate the...
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Anopheles stephensi: The First Vector to Show an Evolutionary Response to Rapid Climate Change
Anopheles stephensi Liston (1901), described primo temporis from its type locality, Ellichpur* (Amroati district, Central Provinces*; Ellichpur is...
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Skin Cancer: An Overview
Skin cancer is one of the most prevalent forms of cancer, comprising two major types: non-melanoma and melanoma. The major cause behind development...
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APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation
BackgroundMutations in p53, identified in 90% of oesophageal squamous cell carcinoma (ESCC), are associated with unfavourable prognosis and...
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Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relative to lower doses, e.g.,...
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A Mathematical Model of Neurohumoral Regulation of the Circulatory System
A mathematical model of the systemic circulation is described. The model takes into consideration the baroreceptor and humoral regulation of the...
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Integrated single-cell and bulk RNA sequencing analysis identifies a neoadjuvant chemotherapy-related gene signature for predicting survival and therapy in breast cancer
Neoadjuvant chemotherapy (NAC) is a well-established treatment modality for locally advanced breast cancer (BC). However, it can also result in...
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Age-adjusted high-dose chemotherapy followed by autologous stem cell transplantation or conventional chemotherapy with R-MP as first-line treatment in elderly primary CNS lymphoma patients – the randomized phase III PRIMA-CNS trial
BackgroundOlder primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available...
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CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status
Chaperonin-containing TCP1 (CCT) is a multi-subunit complex, known to participate the correct folding of many proteins. Currently, the mechanism...
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Investigation of the Dead Body
One of the greatest sources of physical evidence is the dead body of the victim itself. A cadaver is a plethora of clues, that forensic scientists...
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Genetic Diversity of Old and Local Apple (Malus × domestica Borkh.) Cultivars of Volga Region from VIR Collection Inferred from NBS-Profiling
AbstractIntraspecific polymorphism of the NBS-LRR resistance genes sequences of 112 old and local apple cultivars of Volga region from the collection...
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An innovative strategy for deworming dogs in Mediterranean areas highly endemic for cystic echinococcosis
BackgroundCystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus sensu lato , is a zoonotic parasitic disease of economic...
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ROS, Redox Regulation, and Anticancer Therapy
This chapter entitled “ROS, Redox Regulation, and Anticancer Therapy” includes all redox-regulated cancer therapy events. Here in this chapter...
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A novel upregulated hsa_circ_0032746 regulates the oncogenesis of esophageal squamous cell carcinoma by regulating miR-4270/MCM3 axis
IntroductionCircular RNAs (CircRNA) have emerged as an interest of research in recent years due to its regulatory role in various kinds of cancers of...
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The Effects of Externally Paced Exercise on Executive Function and Stress in College-Aged Students
PurposeThe purpose of the study was to investigate the acute effect of a beginner martial art class and aerobic exercise on executive function (EF)...
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Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial
Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite a paucity of...
