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NBAS Variants Are Associated with Quantitative and Qualitative NK and B Cell Deficiency
PurposeBiallelic pathogenic NBAS variants manifest as a multisystem disorder with heterogeneous clinical phenotypes such as recurrent acute liver...
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The relevance of ototoxicity induced by radiotherapy
BackgroundThe risk of ototoxicity, characterized by hearing impairment, tinnitus, or middle ear inflammation, is elevated in both child and adult...
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Clinical Trials of Bacteriophage Therapeutics
The 100-year anniversary of the discovery of bacteriophages has come and gone. After being overshadowed by the limelight success of penicillin in the...
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Fifty years devoted to anaerobes: historical, lessons, and highlights
Renew interest and enthusiasm for anaerobes stem from both technological improvements (culture media, production of an adequate anaerobic atmosphere,...
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In vivo Pharmacokinetics/Pharmacodynamics Profiles for Appropriate Doses of Cefditoren pivoxil against S. pneumoniae in Murine Lung-Infection Model
PurposeCefditoren, the active form of cefditoren pivoxil, is an oral cephalosporin antimicrobial drug. Although cefditoren exhibits high...
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Respiratory Syncytial Virus
Every year, millions of people are infected by the respiratory syncytial virus (RSV). Respiratory syncytial virus widely infects children as well as...
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Two novel mutations in the DNAH11 gene in primary ciliary dyskinesia (CILD7) with considerable variety in the clinical and beating cilia phenotype
BackgroundDiagnosis of primary ciliary dyskinesia (PCD) still remains a challenge, especially with mutations in the Dynein Arm Heavy Chain 11 ( DNAH11 ...
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Teaching prudent antibiotic use on the go: a descriptive report on development, utilization and listener satisfaction of an educational podcast format for medical students and young professionals
BackgroundAn important component in fostering the responsible use of antibiotics is training of new and future prescribers in this interdisciplinary...
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Vibrio, Aeromonas and Plesiomonas
Members of the family Vibrionaceae are aerobes and facultative anaerobes, non-sporing, catalase and oxidase positive. They reduce nitrates to...
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Association between Ca2+ Signaling Pathway-Related Gene Polymorphism and Age-Related Hearing Loss in Qingdao Chinese Elderly
AbstractStudies have revealed that Ca 2+ is essential for normal hearing. This study explored the association between age-related hearing loss (ARHL)...
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Mendelian Susceptibility to Mycobacterial Disease (MSMD): Clinical, Immunological, and Genetic Features of 22 Patients from 15 Moroccan Kindreds
PurposeThe first molecular evidence of a monogenic predisposition to mycobacteria came from the study of Mendelian susceptibility to mycobacterial...
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Antimicrobial Activity of **bornol and a **bornol-Based Formulation Against Gram-Positive Pathogens of the Respiratory Tract
**bornol is known since the 70s and a xibornol-based formulation is commercialized as spray suspension for the antisepsis of the oral cavity and as...
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Phenotypic characteristics and variability in CHARGE syndrome: a PRISMA compliant systematic review and meta-analysis
BackgroundCHARGE syndrome (OMIM #214800) is a phenotypically complex genetic condition characterised by multi-system, multi-sensory impairments....
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The role and influence of bacteria on the growth of Blastocystis sp. subtype 3
Blastocystis sp . is an enteric protistan parasite that affects individuals worldwide with gastrointestinal symptoms such as abdominal discomfort,...
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Characteristics and whole-genome analysis of a novel Pseudomonas syringae pv. tomato bacteriophage D6 isolated from a karst cave
Pseudomonas syringae is a gram-negative plant pathogen that infects plants such as tomato and poses a threat to global crop production. In this...
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Audition: Hearing and Deafness
Among the senses, the mechanical ones, hearing, balance, touch, and proprioception, are most numerous but least understood. The status of hearing is...
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Asymptomatic nasopharyngeal bacterial carriage, multi-drug resistance pattern and associated factors among primary school children at Debre Berhan town, North Shewa, Ethiopia
BackgroundNasopharyngeal carriage of bacteria is the main source for transmission of pathogens across individuals and horizontal spread of organisms...
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The Role of Pyroptosis and Autophagy in the Nervous System
Autophagy is a conservative self-degradation system, which includes the two major processes of envelo** abnormal proteins, organelles and other...
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Inflammation and Neutrophil Oxidative Burst in a Family with NFKB1 p.R157X LOF and Sterile Necrotizing Fasciitis
Loss-of-function (LOF) mutations in NFKB1 , coding for p105, may cause common variable immunodeficiency due to dysregulation of nuclear factor...
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Human Bocavirus
The Human Bocavirus (HBoV) was identified in Sweden over 10 years ago as a non-enveloped virus with linear ssDNA and was grouped under Parvoviridae....