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Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma
BackgroundGlia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a...
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Epigallocatechin-3-gallate and its nanoformulation in cervical cancer therapy: the role of genes, MicroRNA and DNA methylation patterns
Green tea, a popular and healthy nonalcoholic drink consumed globally, is abundant in natural polyphenols. One of these polyphenols is...
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High-Mobility Group Box 1 in Spinal Cord Injury and Its Potential Role in Brain Functional Remodeling After Spinal Cord Injury
High-mobility group box 1 (HMGB1) is a nonhistone nuclear protein, the functions of which depend on its subcellular location. It is actively or...
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Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets
BackgroundThe emergence and spread of malaria drug resistance have resulted in the need to understand disease mechanisms and importantly identify...
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Vitamin D and biomarkers of inflammation and oxidative stress among pregnant women: a systematic review of observational studies
ObjectiveThis systematic review aimed to map the evidence evaluated the relationship between vitamin D and redox and inflammatory status during...
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Modeling with Biomarkers: Nitrosamines and Phytochemical Protection
Humans may be exposed to nitrosamines through agricultural pesticides, cosmetics, pharmaceutical preparations, and food preservatives, which are all...
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Ideal Synbiotics: Pharmacokinetic, Pharmacodynamic, and Safety Assessment
Functional foods are becoming increasingly popular as people become more interested in maintaining their health and preventing diseases. Synbiotics...
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Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
BackgroundWilms tumor (WT) exhibits structural and epigenetic changes at chromosome 11p15, which also cause Beckwith-Wiedemann Syndrome (BWS)....
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Nicardipine Inhibits Priming of the NLRP3 Inflammasome via Suppressing LPS-Induced TLR4 Expression
The Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex composed of NLRP3, pro-caspase-1, and apoptosis-associated speck-like...
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Understanding the Renin-Angiotensin System in Coronavirus Disease 2019
At the beginning of the COVID-19 pandemic, there was increasing concern that therapy with renin-angiotensin-system (RAS) inhibitors, such as...
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Morphological and Molecular Biological Features of the Systemic Inflammatory Response in Old Wistar Rats with High and Low Resistance to Hypoxia
Morphological and molecular biological features of LPS-induced systemic inflammatory response were assessed in old male Wistar rats with high (HR)...
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Integrated Single Cell Analysis Reveals An Atlas of Tumor Associated Macrophages in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC), one of the most prevalent cancers globally, is closely associated with tumor-associated macrophages (TAMs), including...
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Study on the Role of Salivary Flora and NF-κB Inflammatory Signal Pathway in Oral Lichen Planus
Oral lichen planus (OLP) is an inflammatory disease. It is believed that infection and immune dysfunction play a key role in its pathogenesis, but...
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HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of...
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HDL and Sepsis
Sepsis has been recognized as a global health burden in the year 2017 for its high morbidity and mortality. HDL, a cholesterol transporter, also...
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Renin–Angiotensin–Aldosterone System and LOX-1 Interaction in Hypertension with a Focus on Modulation of the Immune System
The renin–angiotensin–aldosterone systemRenin-angiotensin-aldosterone system (RAAS) plays a key role in the pathological process of many...
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MicroRNA-766-3p-mediated downregulation of HNF4G inhibits proliferation in colorectal cancer cells through the PI3K/AKT pathway
Nuclear receptors (NRs) are a class of transcription factors that play a pivotal role in carcinogenesis, but their function in colorectal cancer...
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IL-10: A Key Molecule in the Mitigation of Heart Failure
Inflammatory mediators play an important role in the pathogenesis of several diseases including heart failure. An appropriate balance between...
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TNIK in disease: from molecular insights to therapeutic prospects
TRAF2 and NCK interacting kinase (TNIK), a critical interacting protein kinase, is currently receiving wide attention. TNIK is found in various human...
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H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway
Cellular senescence serves as a fundamental and underlying activity that drives the aging process, and it is intricately associated with numerous...
