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Effect of alpha-lipoic acid and caffeine-loaded chitosan nanoparticles on obesity and its complications in liver and kidney in rats
The present work investigated the effect of α-lipoic acid (ALA) and caffeine-loaded chitosan nanoparticles (CAF-CS NPs) on obesity and its hepatic...
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Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
One of the greatest challenges with successful pharmaceutical treatments of central nervous system (CNS) diseases is the delivery of drugs into their...
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Possible Antinociceptive Mechanisms Triggered by Nanomolar Ouabain Concentrations in Primary Sensory Neurons
The responses of primary sensory neurons to subnanomolar and nanomolar ouabain concentrations, corresponding to the endogenous ouabain (EO)...
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ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium...
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Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts
Recent results from data mining analyses and reports of adverse drug events suggest a QT-prolonging drug–drug interaction resulting from the...
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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
BackgroundDisturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast...
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Current Updates on Potential Role of Flavonoids in Hypoxia/Reoxygenation Cardiac Injury Model
Clinically, timely reperfusion strategies to re-establish oxygenated blood flow in ischemic heart diseases seem to salvage viable myocardium...
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The role of HCO3– in propionate-induced anion secretion across rat caecal epithelium
Propionate, a metabolite from the microbial fermentation of carbohydrates, evokes a release of epithelial acetylcholine in rat caecum resulting in an...
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Upregulation of Uric Acid Production and Caspase 3 Signalling Mediates Rohypnol-Induced Cardiorenal Damage
The global prevalence of illicit drug use is on the increase with attendant complications like cardiorenal collapse. One such substance of abuse is...
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Oxidative and Nitrous Stress Underlies Vascular Malfunction Induced by Ionizing Radiation and Diabetes
Oxidative stress results from the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in quantities exceeding the...
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Current Topics of Optogenetics for Medical Applications Toward Therapy
The optogenetics approach uses a combination of genetic and optical methods to initiate and control functions in specific cells of biological...
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Electrical and Mechanical Properties of Vascular Smooth Muscle
Vascular Smooth Muscle (VSM) manifests unique electrical and mechanical properties which impart profound influences on vascular contractility. The...
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Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
IntroductionPosthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and...
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Cardiac Ion Channels and Heart Rate and Rhythm
The excitability of the heart is a prerequisite for its function as a pump distributing blood throughout the body. Initiated in the sinoatrial node,...
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Voltage-Gated Ion Channels
Electric signaling by ion channels is a fundamental regulatory pathway in all organisms, from prokaryotes to humans. Voltage-gated ion channels for...
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Activation of Dopamine D2 Receptors Alleviates Neuronal Hyperexcitability in the Lateral Entorhinal Cortex via Inhibition of HCN Current in a Rat Model of Chronic Inflammatory Pain
Functional changes in synaptic transmission from the lateral entorhinal cortex to the dentate gyrus (LEC-DG) are considered responsible for the...
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Exome sequencing of ATP1A3-negative cases of alternating hemiplegia of childhood reveals SCN2A as a novel causative gene
Alternating hemiplegia of childhood (AHC) is a rare neurodevelopment disorder that is typically characterized by debilitating episodic attacks of...
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Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts
Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular dysfunction via the pleiotropic effects behind their receptor action....
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Effects of Noopept and Piracetam on Depression of the Acetylcholine-Induced Current in Common Snail Command Neurons
The actions of the nootropes noopept and piracetam on depression of the acetylcholine-induced current in a cellular analog of habituation were...
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New saliva secretion model based on the expression of Na+-K+ pump and K+ channels in the apical membrane of parotid acinar cells
The plasma membrane of parotid acinar cells is functionally divided into apical and basolateral regions. According to the current model, fluid...
